摘要
目的:评价经肝动脉注射32P-玻璃微球治疗肝癌的临床疗效,并测定其对肿瘤组织多药耐药基因的表达率的影响。方法:116例原发性肝癌随机分成两组,A组58例,TACE+32P-GMS治疗;B组58例,单纯TACE治疗。每例分别在B超或CT引导下经皮穿刺活检,获取肿瘤组织标本,运用RT-PCR法定量分析mdr-1基因表达水平,根据影像学判定肿瘤血管侧支循环、肿瘤缩小情况、血清AFP下降率,比较两种方案的疗效。结果:①血管造影:A组肿瘤血管栓塞程度为97%±3%,侧支循环形成很少;B组肿瘤血管栓塞的程度为90%±8%,有侧支循环形成;②肿瘤坏死面积:A组为76%±17%,B组为60%±14%;③肿瘤缩小平均值:A组为60.54%±10.14%;B组为43.27%±9.12%;④AFP下降率:A组为84.48%;B组为51.72%;⑤1年生存率:A组为81%,B组为56%;⑥mdr-1cDNA\β2-mGcDNA:A组为0.3036±0.0825;B组为0.4755±0.1259。所有数据经μ检验或χ2检验,A组疗效优于B组,统计学上有显著差异(P<0.01)。结论:TACE+32P-GMS治疗原发性肝癌疗效优于单纯应用TACE。
Objective：To evaluate the clinical efficacy of the two therapy plans in treatment of pdmary liver cancer （PLC）. Methods： 116 cases of PLC were divided randomly into two groups. Group A： 58 cases were treated by the second therapy plan （TACE and 32^P-GMS） .Group B： 58 eases were treated by the first therapy plan （TACE） ; The PLC tissue of every ease was obtained by pereutaneous biopsy under the guide of CT or B-ultrasound pre-and post interventional therapy. The expression level of mdrl gene was quantified by RT-PCR. The efficacy of two procedures was compared according to the angiographie appearance, necrotic percentage, volume of the tumor, changes of AFP level, the ratio of mdr-1 eDNA and β2-mGcDNA.Results：①Aeeording to angiographie appearance, the embolization of tumor arteries is 97% ± 3% in group A, and by-pass circulation is few. The embolization of tumor arteries is 90% ± 8% in group B, and by-pass circulation had fomled; ②The average decreased size of tumor is 60.54% ± 10.14% in group A;43.27% ± 9.12% in group B; ③The incidertee of AFP deeresed is 84.48% in group A; 51.72% in group B; ④The necrotic percentage of tumor is 76% ± 17% in group A; 60% ± 14% in group B;⑤The incidence of one year survivalrate is 81% in group A; 56% in group B;⑥The ratio of mdr-1 eDNA and β2-mGeDNA is 0. 3036 ± 0.0825 in group A; 0.4755 ± 0. 1259 in group B. （ P 〈 0.01 ）. Candusion：The second therapy plan is more effieient than the first therapy plan in the treatment of PLC.
出处
《医学影像学杂志》
2005年第8期678-681,共4页
Journal of Medical Imaging
基金
山东省卫生厅计划课题(1999CAICCB2)
关键词
经肝动脉化疗栓塞术
32^P-玻璃微球
多药耐药基因
原发性肝癌
Tmnscatheter arterial chemoembolization （TACE）
32^P-glass microsphere （32^P-GMS）
Multidrug-resistancegene
Primary hepatic carcinoma
