摘要
目的:探讨首发抑郁症患者的糖代谢功能。方法:对142例首发抑郁症患者(患者组)检测空腹血糖(FPG)及糖耐量试验2h血糖(2hPG),采用汉密尔顿抑郁量表(HAMD)进行测评并与142名健康人进行对照(对照组)。结果:患者组2hPG明显高于对照组(P=0.023);患者组糖调节异常(IGR)的发生率为11.3%显著高于对照组的4.2%(χ2=4.93,P=0.026);患者组FPG、2hPG与HAMD评分间无显著相关性(P=0.334,0.267)。Logistic回归分析显示,患者组更易发生IGR(OR=3.68)。结论:首发抑郁症患者的糖代谢功能与正常人群存在差异,抑郁症可能是IGR的一个危险因素。
Objective：To investigate the function of glucose metabolism in first-episode patients with depression. Method：First-episode patients with depression （ 142 cases） and healthy controls （ 142 cases） were involved in the study. The fasting plasma glucose （FPG） and 2 hour plasma glucose （2 hPG） in the oral glucose tolerance test were examined in two groups. Hamilton rating scale of depression was administered to two groups. Results ：2 hPG was significantly higher in patients than that in controls （ P = 0.023 ）. The prevalence of impaired glucose regulation（IGR） was significantly higher in patients than in controls（ 11.3% vs 4.2%, χ^2 = 4.93 ,P = 0. 026 ）. There was no significant correlation between FPG/2 hPG and HAMD total scores（ P = 0. 334,0. 267 ）. Logistic regression analysis indicated that depression had higher risk of IGR （ OR = 3.68 ）. Conclusion ： The function of glucose metabolism in first-episode patients with depression is different from that in healthy controls, and depression may be considered as a risk factor of IGR.
出处
《临床精神医学杂志》
2009年第6期385-387,共3页
Journal of Clinical Psychiatry
关键词
抑郁症
糖代谢功能
糖调节异常
depression
glucose metabolism function
impaired glucose regulation
