摘要
目的探讨凋亡抑制基因Survivin的表达与非小细胞肺癌(NSCLC)生物学特征及临床预后的关系。方法应用免疫组化检测了70例NSCLC中Survivin的表达,并选取30例癌旁组织作为对照,比较Survivin的表达与NSCLC患者生物学特征及预后的关系。结果Survivin在NSCLC中的阳性表达率为74.3%,而癌旁组织无1例表达,Survivin的表达与肺癌患者年龄、性别、病理类型、分化程度无关(P>0.05),与临床分期有关(P=0.008);Survivin表达阳性者生存时间明显低于阴性表达者(P=0.000),COX回归显示Survivin与NSCLC患者预后有关(P=0.001)。结论Survivin与NSCLC的发生发展有关,过度表达提示预后不良,Survivin有望成为肺癌诊断和基因治疗的新靶点。
Objective To evaluate the relationship between expression of survivin and its biological characteristic, pognosis in non-small cell lung cancer（ NSCLC ）. Methods The expression of survivin in 70 patients with NSCLC and in 30 patients with the lung tissue of non-carcinoma was examined by immunohistochemical methods. The expression of survivin was compared with biological characteristics and prognosis of NSCLC. Results The positive expression rate of survivin was 74. 3 %, and there was no expression of survivin in adjacent normal lung tissues. There were no correlation between survivin and age, sex, differentiation and histological classification （ P 〉 0. 05 ）. There was correlation between survivin and clinical stage（ P = 0. 008 ）. And the survival time of NSCLC person in the positive expression of aurvivin was shorter than the negative expression （P = 0. 000）. The COX regression showed that survivin expression was related with prognosis of NSCLC （ P = 0. 001 ）. Conclusion There is close relationship between survivin and NSCLC, the over-expression of survi- ving suggests the bad prognosis in NSCLC ,Survivin gene may be identified as a defining diagnostic marker and a potential therapeutic target in NSCLC.
出处
《临床肺科杂志》
2010年第1期5-6,共2页
Journal of Clinical Pulmonary Medicine
