摘要
目的探讨在生活方式改善的基础上用罗格列酮钠对空腹血糖受损(impaired fasting glucose,IFG)患者进行综合强化干预治疗的效果。方法将137例空腹血糖受损患者随机分成单纯生活方式干预组(健康教育+饮食+运动,n=68)和综合强化方式干预组(罗格列酮钠+运动+饮食,n=69),观察6个月。监测、对比、分析两组患者体质量指数(body mass index,BMI)、腰臀比(waist-hip ratio,WHR)、总胆固醇(total cholesterol,TC)、甘油三酯(total glycerin,TG)、低密度脂蛋白胆固醇(lowdensity lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、血尿酸(uric acid,UA)、空腹血糖(fasting plasma glucose,FPG)、餐后2h血糖(postprandial2hours plasma glucose,2hPG)、空腹胰岛素(fasting insulin,FINS),餐后2h胰岛素(2hours fasting insulin,2hINS),糖化血红蛋白(glycohemoglo-bin,HbA1c),并2h/NS进一步计算胰岛素分泌指数(insulin secretion index,HOMA-IS)和胰岛素抵抗指数(insulin resistance index,HOMA-IR)等指标。结果①综合强化干预组的患者,在干预治疗6个月后,TC、TG、LDL-C、UA、FPG、2hPG、FINS、HbA1c等明显下降(P<0·05);②生活方式干预组患者在坚持饮食控制和体育运动治疗6个月后,BMI、WHR、TC、TG、LDL-C、FPG、2hPG、FINS、HbA1c等有一定下降趋势(P>0·05)。结论对IFG患者在接受健康教育的基础上控制饮食、坚持运动,给予罗格列酮钠进行干预治疗是更有积极意义的。
Objective To determine whether rosiglitazone sodium can be used to increase insulin sensitive and improve glucose tolerance in individuals with impaired fasting glucose （IFG） on the basis of rational diet and exercise. Methods Totally 137 patients with IFG was divided into 2 groups randomly, lifestyle intervention group （n = 68）, and the comprehensive strengthening intervention group （rosiglitazone sodium, 4 mg/d, n = 69）. The period of observation was 6 months. The observed items included ： the body mass index （BMI） , fasting plasma glucose （FPG）, postprandial 2-hour plasma glucose （2hPG）, total cholesterol （TC）, total glycerin （TG）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, fasting insulin （FINS）, and glycohemoglobin （HbA1c） were measured. And insulin secretion index （HOMA-IS） and insulin resistance index （HOMA-IR） were calculated. Results After 6 months treatment, we found that FPG, 2hPG, TC, TG, LDL-C, FINS and HbAlc were decreased sharply in the comprehensive strengthening intervention group compared with the values of these parameters before treatment （P 〈 0.05）. After 6 months＇ rational diet and exercise, the lifestyle intervention group had little declined BMI, WHR, TC, TG, LDL-C, FPG, 2hPG, FINS and HbAlc in compared with before intervention （P 〉0.05）. There was no any adverse effect or side effect observed. Conclusion It is recommendable to administer rosiglitazone sodium to the patients with IFG on the basis of rational diet and exercise.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2009年第24期2482-2485,共4页
Journal of Third Military Medical University
关键词
糖尿病
空腹血糖受损
罗格列酮钠
生活方式
干预
diabetes mellitus
impaired fasting glucose
rosiglitazone sodium
lifestyle
interference
