摘要
目的探讨彩色多普勒血流显像评价兔股骨头缺血性坏死髋关节内的血流动力学改变。方法建立激素性兔股骨头缺血性坏死模型18只,分别在注射激素前、给药后4周及10周行彩色多普勒超声检查,观察兔髋关节内的血流改变。同时做数字X线摄影(DR)和磁共振成像(MRI)检查,并检测血清总胆固醇和甘油三酯的变化。给药10周后HE染色观察兔股骨形态变化。结果注射激素后4周及10周与给药前相比兔髋关节内血管的血流速度降低(P<0.05),动脉血流阻力指数增高(P<0.01)。DR未见异常改变,注射激素10周后MRI出现股骨头异常信号。血清总胆固醇和甘油三酯在注射激素后4、10周均较注射前明显升高(P<0.05)。HE染色结果显示股骨头缺血坏死的病理表现。结论彩色多普勒超声能动态监测股骨头缺血性坏死髋关节内血管血流动力学变化。
Objective To investigate the value of color Doppler flow imaging in evaluation of the hip joints＇ blood flow in avascular necrosis of femoral head （ANFH）. Methods Eighteen adult ANFH models were made in New Zealand rabbits by intramuscular injecting 8 mg/kg prednisolone acetate twice per week for 4 weeks followed by once per week for 6 weeks. Color Doppler flow imaging （15L8w, 10.0 to 14.0 MHz） were carried out to examine the hip joints＇ blood supply before the injection, and 4 and 10 weeks after the injection. Digital radiography and magnetic resonance imaging were performed, and serum total cholesterol and triglyceride levels were measured at the same time points. HE staining was used to study the morphological change of the hip joints. Results The flow velocity of the small vessel in the hip joints at 4 weeks and 10 weeks after the injection were significantly lower than before the injection （P 〈 0.05 ）, and artery resistance index （RI） was still increased （P 〈 0.01 ）. There was no obvious changes in the X-ray film after injection, but changes were found in MR image in 10 weeks after the injection. HE staining showed typical avascular necrosis in the femoral head. Conclusion Ultrasonography can evaluate the hip joints＇ blood supply of avascular necrosis of the femoral head.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2009年第24期2463-2465,共3页
Journal of Third Military Medical University
关键词
超声检查
多普勒
彩色
股骨头缺血性坏死
髋关节
血流动力学
兔
uhrasonography, Doppler, color
avascular necrosis of the femoral head
hip joint
hemody-namics
rabbits
