摘要
目的比较自体角膜缘干细胞移植术和术中联合应用丝裂霉素C治疗原发性翼状胬肉临床疗效。方法将103例123只眼患者随机分成两组,分别使用自体角膜缘干细胞移植术(51例61只眼,简称干细胞移植组)和术中联合应用丝裂霉素C(52例62只眼,简称术中联合丝裂霉素C组),术后随访1～2年。结果两组角膜创面上皮愈合时间均为4～7天。干细胞移植组9眼复发,复发率为14.8%。术中联合丝裂霉素C组2眼复发,复发率为3.2%,两组比较差异有显著性(P<0.05)。结论自体角膜缘干细胞移植术中联合应用丝裂霉素C治疗原发性翼状胬肉,角膜创面恢复快,复发率低,是一种理想的手术方法,值得推广应用。
Objective To compare the clinical efficacy of autologous limbus corneae stem cell transplantation and the joint application of intraoperative mitomycin C treatment for primary pterygium.Metbods 103 cases （ with 123 eyes ）were randomly divided into two groups,autologous limbus eorneae stem cell transplantation （51 cases with 61 eyes,referred to as stem cell transplantation group） and the joint appheafion of intraoperative mitomycin C （52 cases with 62 eyes,referred to as Intraoperative Mitomycin Cgroup）,the patients were followed for 1 - 2 years after the operations. The corneal epithelial wound healing time of the two groups were 4 - 7 days.In the stem cell transplantation group,there were. 9 eyes recurred,the recurrence rate was 14.8%.In the Intraoperative Mitomycin C group,there were. 2 eyes recurred,the reeurrenee rate was 3.2%;the differences of these two groups had statistical significance （ x^2=5.018,P〈0. 05）.Conclusions Limbus eomeae siena cell transplantation combined with mitomyein C in the treatment of primary. pterygium,with the good point of comeal wound recovering rapidly and with low recurrence rate.It＇ s an ideal surgical approaeh which should be popularized and applied.
出处
《国际医药卫生导报》
2009年第23期46-47,共2页
International Medicine and Health Guidance News
