摘要
目的探讨经肝动脉灌注p53基因联合栓塞化疗术在治疗原发性肝癌中的应用价值。方法将78例原发性肝癌患者分成实验组及对照组,分别进行肝动脉灌注重组人p53腺病毒注射液联合栓塞化疗术及常规TACE治疗,对术后反应及疗效进行对比分析。结果术后实验组在治疗效果及肝功能都优于对照组,不良反应两组大致相同。结论p53基因联合栓塞化疗术治疗中晚期肝癌是一种安全可行的治疗方法。
Objective To analyze the value of hepatic intraarterial p53 gene administration combined with chemoembolization for the treatment of advanced hepatocellular carcinoma. Methods 78 patients with hepatocellular carcinoma were divided into two groups ： test group and control group. Test group with 22 patients were treated with hepatic intraarterial p53 gene administration combined with chemoembolization. Control group with 56 patients were trented with common chemical drug and lipiodol. The difference in post - operative response and efficacy were studied. Results The efficacy of treatment and liver function in the test group of transarterial chemoembolization were better than those of control group. The incidences of adverse effects were similar between the two groups. Conclusion Hepatic intraarterial p53 gene administration combined with chemoembolization is a safe and feasible in treating patients with hepatocellular carcinoma.
出处
《广东医学》
CAS
CSCD
北大核心
2009年第12期1826-1828,共3页
Guangdong Medical Journal
基金
国家自然科学基金(编号:30600156)
广东省自然科学基金(编号:06021222)
广东省珠海市卫生局课题(编号:2008009)
