摘要
目的通过监测原发性肝癌患者的免疫功能,研究肝癌选择性与超选择性化疗栓塞术后CD4+T、CD8+T、CD4+T/CD8+T比值的改变及其临床意义。方法将入选的40例患者病例随机分为选择性化疗栓塞组和超选择性化疗栓塞组。应用流式细胞术(FCM)检测CD4+T、CD8+T及CD4+T/CD8+T比值。结果选择性化疗栓塞组及超选择性化疗栓塞组病例在治疗后一月检测CD4+T、CD4+T/CD8+T比值较术前均升高,CD8+均降低,有统计学意义。超选择性化疗栓塞组术后CD4+T、CD8+T及CD4+T/CD8+T比值与选择性化疗栓塞组术后相比较,有统计学意义。结论超选择性化疗栓塞与选择性化疗栓塞相比较,其减少或避免了非瘤肝组织的损害,使栓塞更加致密,肿瘤坏死更加彻底,机体免疫功能可得到明显改善。
Objective: To observe the variations of the CD4 +、CD8 + serum level and CD4 +/CD8 + ratio and clinical significance by using select transcatheter hepatic arterial chemoembolization(TACE) and super select transcatheter hepatic arterial chemoembolization(s-TACE) for primary hepatocarcinoma,through detecting immunological function of primary hepatocarcinoma.Methods: The patients were 40 cases.The patients were randomly divided into TACE group and s-TACE group.The CD4 +、CD8 + serum level and CD4 +/CD8 + ratio w...
出处
《泰山医学院学报》
CAS
2009年第11期841-843,共3页
Journal of Taishan Medical College
关键词
原发性肝癌
经导管肝动脉化疗栓塞术
T细胞
primary hepatocarcinoma
super select transcatheter hepatic arterial chemoembolization（s-TACE）
T lymphycytes
