摘要
目的探讨MMP-9、TIMP-1水平与脑梗死TOAST分型及预后的关系。方法收集急性脑梗死患者90例,按照TOAST分型分为CE、LAA、SA三组;对照组30例;采用ELISA法,测定发病24 h内、第5 d和第10 d的血清MMP-9、TIMP-1;对照组采清晨空腹血1次,测定血清MMP-9、TIMP-1含量。随访1个月,记录发病1个月时的BI(Barthal Index)来评价预后含量。结果发病后24 h内,TOAST各亚型血清MMP-9含量均升高,与对照组比较差异有统计学意义(P<0.05),其中,CE组和LAA组高于SA组(P<0.05);第14 d各组MMP-9含量均降至正常水平。发病后24 h内,TOAST各亚型血清TIMP-1含量亦均升高,与对照组比较差异有统计学意义(P<0.05),其中,CE组和LAA组高于SA组(P<0.05);第14 d各组TIMP-1含量均降至正常水平。预后较好者其发病24 h内血清MMP-9含量为(567.1±263.0)ng/ml,明显低于预后较差者,其MMP-9含量为(893.7±451.1)ng/ml,两者比较差异有统计学意义(P<0.05)。结论MMP-9作为生物活性指标,有助于急性脑梗死的分型,并为我们提供病变程度和预后的信息,同时也可以作为我们评定预后的指标之一。
Objective To study the relationship among the levels of serum MMP- 9, TIMP- 1 and the classification of TOAST and the significance in prognosis in patients with cerebral infarction. Methods Ninety patients with cerebral infarction were included in our study, while 30 healthy people served as the control group. According to TOAST, the patients were divided into three subtypes： CE, LAA, and SA. The serum specimens were gathered for MMP -- 9 and TIMP- 1 determination with ELISA on admission, at the 7^th and 14th days of onset. All patients were recorded Barthal index （BI） on the first month of onset. Results The serum level of MMP- 9 increased after cerebral infarction, and were significantly higher than that in the control group （P〈 0.05）. MMP- 9 in CE and LAA groups was significantly higher than that in SA group （P〈 0.0.5）. At the 14^th day MMP- 9 in all groups decreased to normal. The serum level of TIMP - 1 increased after cerebral infarction, and were significantly higher than that in the control group （P〈 0.0.5）. TIMP- 1 in CE and LAA groups were significantly higher than that in SA group （P〈 0.05）. At the 14th day TIMP- 1 in all groups decreased to normal. The serum level of MMP- 9 in the patientS with better prognosis （567. 1 ± 253.0 ng/ml） was significantly lower than that in the patients with poor prognosis （893.7 ± 451.1 ng/ml）, there was a statistically significant difference between them （P〈0.05）. Conclusions The level of serum MMP - 9 within 24 hours of onset can reflect the classification, and also can use as an independent indicator of prognosis.
出处
《实用预防医学》
CAS
2009年第6期1892-1894,共3页
Practical Preventive Medicine
