摘要
目的研究致命药品不良事件(ADE)发生的类型与特点。方法结合Excel电子表格和手工筛选,建立ADR报表数据库,对2004年1月～2009年6月各医疗机构和社会药房上报湖南省药品不良反应监测中心的115例致命药品不良事件报表进行统计分析,统计内容包括患者的一般情况、致命ADE病例发生的医疗机构、致命ADE的表现、怀疑药品及导致的系统-器官损害、死亡原因等。结果致命药品不良事件大部分发生在基层卫生机构,可发生于任何年龄段,以变态反应最为常见,导致死亡的ADE以过敏性休克占绝大多数。结论抗微生物药、中药注射剂、生物制品是发生致命ADE最多的三类药物。同时应重视致命ADE,对于有药物过敏史或过敏体质的患者,应严密观察用药过程中的反应,及早发现过敏性体克的发生,并及时采取抢救措施,以减少过敏性休克所导致死亡的发生。
[ Objective ] To study the category and the characteristics of fatal adverse drug events. [ Methods ] 115 cases fatal adverse drug events collected by Hunan Drug Adverse Reactions Monitoring Center from January 2004 to Jane 2007 were statistical analysed, binding Excel electron table and hand-made select, estab/ishing ADR report forms data. The contents of statistics included general state of patients, medical establishment occurred fatal adverse drug events, the damage of organ/system and cause of death. [ Results ] Most of fatal adverse drug events took place at primary level medical establishment. The fatal adverse drug events can occur any ages, with all kinds of clinical manifestations. The most common is allergies. Most of fatal adverse drug events caused by anaphylaetic shock. [ Conclusion ] Antimicrobial drugs, injections of Chinese crude drug and biological products were three kinds of drugs that most of fatal adverse drug events occurred. The fatal adverse drug events should be attached great im- portance to. Drugs should be used with caution in patients with a history of hypersensitivity, to discover allergic shock early and to adopt rescue measures promptly in order to reduce the death caused by allergic shock.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第22期3500-3504,共5页
China Journal of Modern Medicine
