摘要
目的观察多西他赛(DOC)联合奥沙利铂(OXA)周剂量方案一线治疗高龄晚期胃癌的临床疗效及不良反应。方法对30例晚期胃癌患者,采用DOC 35mg/m2,静脉滴注d1,d8;OXA 70 mg/m2,静脉滴注d1,d8;21d为1周期,至少2个周期后评价疗效。结果26例可评价疗效,按RECIST标准评价近期疗效和不良反应,以CR+PR为有效,其中CR 4例,PR 14例,SD 6例,PD 2例,RR 69.23%,中位疾病进展时间为5.8个月,中位生存期11.8个月。不良反应主要是骨髓抑制,外周神经炎和胃肠道反应,均为可逆性。本组无治疗相关性死亡。结论多西他赛联合奥沙利铂每周疗法治疗晚期胃癌疗效确切,不良反应轻,患者耐受性好,值得临床推广。
Objective To determine the efficacy and toxicity of weekly doeetaxel（DOC） in combination with oxaliplatin （OXA） as first-fine treatment on elderly patients with advanced gastric cancer. Methods 30 patients of advanced gastric cancer were treated with docetaxel 35 mg/m^2,ivgtt, d1. d8 ; oxaliplatin 70mg/m^2, ivgtt, dl. d8 ; repeated every 3 weeks （ one cycle ）, The effect was evaluated after two eyeles. The efficacy and toxicity were evaluated according to WHO standard. Results 26 patients might be evaluated for clinical response, complete response in 4 pts and partial response in 14 pts were observed with on overall response rate of 69.23% ,Median time to progression（MTTP）was 5.8 months and median overall survival （MST） was11. 8 months. The most common toxicities were bone marrow suppression, peripheral neuritis, nausea and vomiting. All of them are revesible. There was on treatment related death. Conclusion Combining weekly docetaxel and oxaliplatin is an effective and better tolerated alternative treatment on elderly patients in advanced gastric cancer and yields promising activity.
出处
《四川医学》
CAS
2009年第11期1725-1727,共3页
Sichuan Medical Journal
关键词
晚期胃癌
多西他赛
奥沙利铂
化疗
每周疗法
advanced gastric cancer
docetaxel
oxaliplatin
chemotherapy
weekly
