摘要
目的:探讨多西他赛+顺铂+5-氟脲嘧啶(DCF)与奥沙利铂+四氢叶酸钙+5-氟脲嘧啶(FOLF0X4)化疗方案治疗晚期胃癌的临床疗效,生活质量改善率及不良反应。方法:104例晚期胃癌患者随机分为两组,A组52例,B组52例。A组采用DCF化疗方案治疗,B组采用FOLFOX4化疗方案治疗。两组均治疗两个化疗周期以上。结果:两组近期有效率分别为65.4%(34/52),67.3%(35/52),两组比较,差异无统计学意义(P>0.05);A组生活质量改善率59.6%(31/52),B组生活质量改善率为80.8%(42/52),两组有效率比较,有统计学差别(P<0.05);A组I、Ⅱ度白细胞减少、恶心,呕吐、脱发明显高于B组,两组比较,差异有显著性(P<0.05),但患者能耐受。周围神经炎的发生以FOLFOX4方案居多,两组比较,差异有统计学意义(P<0.05)。结论:DCF和FOLFOX4方案都是治疗晚期胃癌近期疗效较好的方案,不良反应能耐受,但对体质差、骨髓耐受差和年龄大的患者FOLFOX4方案更舍适,生活质量改善方面FOLFOX4方案组优于DCF方案组,而在临床方案选择时,提示可根据不同患者的实际情况选择。
Objective： To compare the short-term efficacy, improvement of QOL and toxicity of DCF （Docetaxel＋ cisplatin＋5-fluorouracil） regimen and FOLFOX （oxaliplatin ＋5-fluorouracil ＋leucovorin） regimen for advanced gastric carcinoma. Methods： A total of 104 gastric carcinoma patients were randomly divided into DCF regimen group （n= 52） and FOLFOX4 regimen group （n=52）. All patients received two courses of chemotherapy. Results： The response rate （RR） was 65.4% in DCF regimen group and 67.3% in FOLFOX4 regimen group, with no significant difference （P〉0.05）. The improvement of QOL in FOLFOX4 regimen group and DCF regimen group was 59.6% （31/52） and 80.8% （42/52）, respectively, with a significant difference （P〈0.05）. Toxic and side effects included bone marrow depression, defluvivm and peripheral neuritis which were tolerable. The incidence of bone marrow depression was higher in DCF regimen group than that in FOLFOX4 regimen group （P〈0.05）. The incidence of peripheral neuritis was higher in FOLFOX4 regimen group than that in DCF regimen group （P〈0.05）. Conclusion： DCF regimen and FOLFOX regimen are effective as first-line treatment for advanced gastric carcinoma. For the improvement of QOL, FOLFOX4 regimen is better than DCF regimen. FOLFOX4 regimen is more suitable for old and weak patients or those with leucopenia after chemotherapy.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2009年第8期205-207,共3页
Chinese Journal of Clinical Oncology
关键词
晚期胃癌
多西他赛
顺铂
氟脲嘧啶
奥沙利铂
化学治疗
Advanced gastric cancer
Docetaxel
Cisplatin
5-fluorouracil
Oxaliplatin
Chemotherapy
