摘要
目的:探讨局部晚期非小细胞肺癌(NSCLC)βⅢ-tubulin和Stathmin表达与紫杉醇化疗耐药性关系。方法:回顾性分析84例接受紫杉醇化疗的局部晚期NSCLC患者的临床病理资料。免疫组织化学法检测肿瘤标本βⅢ-tubulin和Stath-min蛋白的表达,并对疗效进行分析。结果:βⅢ-tubulin阳性表达率为48.81%(41/84),Stathmin阳性表达率为51.19%(43/84),均与性别、年龄及组织类型无关。化疗有效率(CR+PR)为41.67%,βⅢ-tubulin高表达的患者有效率低(24.39%),进展率高(13.89%);βⅢ-tubulin低表达患者有效率高(58.14%),进展率低(0),差异均有显著性(P<0.01)。Stathmin(+)组的有效率为27.91%,低于Stathmin(-)组的56.10%,而其进展率为11.63%,高于Stathmin(-)组0,差异均有显著性(P<0.05)。联合检测显示:βⅢ-tubulin(+)且Stathmin(+)组有效率为21.88%,βⅢ-tubulin(-)且Stathmin(-)组有效率为62.50%,两者差异显著(P<0.01)。结论:βⅢ-tubulin和Stathmin高表达的局部晚期NSCLC患者对紫杉醇化疗耐药。
Objective：To investigate the expression of βⅢ-tubulin,stathmin protein and chemoresistance to paclitaxel in locally advanced non-small cell lung cancer（NSCLC）.Methods：Eighty-four patients of locally advanced NSCLC treated with paclitaxel were enrolled in this study and their tumor samples were collected retrospectively for analysis.The expression of βⅢ-tubulin,stathmin protein in tumor samples was detected by the immunohistochemical methods.The data of therapeutical effect were collected and analyzed.Results：The βⅢ-tubulin positive staining（≥50% of stained cells） accounted for 48.81%（41/84）.The stathmin positive staining（≥50% of stained cells） accounted for 51.19%（43/84）.There was no correlation between βⅢ-tubulin,stathmin positive expression and age,gender,pathological type.The response rate（CR＋PR） was 41.67%.Patients with overexpression βⅢ-tubulin were less response rate（24.39% vs.58.14%） and more progression rate（13.89% vs.0） to paclitaxel（P〈0.01）.Patients with overexpression stathmin were less response rate（27.91% vs.56.10%） and more progression rate（11.63% vs.0） to paclitaxel（P〈0.05）.Patients with overexpression βⅢ-tubulin and stathmin were also lower response rate（21.88% vs.62.50%,P〈0.01）.Conclusion：Overexpression of βⅢ-tubulin,stathmin in tumor cells was associated with resistance to paclitaxel in patients with local advanced NSCLC receiving paclitaxel-based chemotherapy.
出处
《临床肿瘤学杂志》
CAS
2009年第10期884-889,共6页
Chinese Clinical Oncology
基金
河北省科技计划支撑项目(072761486)
