摘要
目的探讨甲状腺转录因子-1在肺外神经内分泌肿瘤中的表达,确定TTF-1在肺内和肺外神经内分泌肿瘤中的鉴别诊断价值。方法应用免疫组化EnVision法检测71例肺外神经内分泌肿瘤中TTF-1的表达。结果18例肺外小细胞癌中TTF-1阳性表达率为44.4%,主要表达于食管小细胞癌。所有肺外类癌、恶性肿瘤伴有神经内分泌分化和Merkel细胞癌均不表达TTF-1。结论TTF-1可在肺外小细胞癌中表达,TTF-1在区分肺内与肺外小细胞癌的鉴别诊断中没有价值,但可区分Merkel癌和内脏小细胞癌转移至皮肤。TTF1在肺原发性类癌和肺外类癌的鉴别诊断中可能有一定价值。
Purpose To study the expression of the thyroid transcription factor 1（TTF-1）in extrapulmonary endocrine tumor.Methods The TTF-1 expression in 72 cases of extrapulmonary endocrine tumor was detected by EnVision immunohistochemical technique.Results The positive rate of the TTF-1 in extrapulmonary small cell carcinoma was 44.4%,mainly in esophageallesions.No expression of TTF-1 was detected in all of extrapulmonary carcinoid,malignant tumor with endocrine differentiation and Merkel cell carcinoma.Conclusions TTF-1 can be expressed in extrapulmonary small cell carcinoma.TTF-1 expression is not specific for small cell carcinoma of pulmonary origin and is not helpful in the distinction between primary and metastatic small cell carcinoma in extrapulmonary sites.However,TTF-1 expression may be useful in distinguishing Merkel cell carcinomas and cutaneous metastasis of small cell carcinomas.TTF-1 may assist in distinguishing lung carcinoid from some extrapulmonary carcinoid.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2009年第5期507-509,共3页
Chinese Journal of Clinical and Experimental Pathology
