摘要
【目的】观察甲状腺转录因子1(TTF-1)在肝脏良、恶性病变中的表达差异,探讨其在肝脏良、恶性病变鉴别诊断中的意义。【方法】采用免疫组织化学S-P法检测了123例正常肝组织、33例肝结节状增生、27例肝腺瘤和68例肝细胞癌组织中TTF-1的表达。【结果】TTF-1在正常肝组织、肝结节状增生、肝腺瘤和肝细胞癌中的阳性表达部位为胞浆,其阳性率分别为89.4%(110/123)、84.8%(28/33)、85.2%(23/27)、41.1%(28/68);在肝细胞癌中的表达明显低于其他三种肝组织,差异具有统计学意义(P=0.000),且其表达与肝细胞癌分化程度具有相关性(P=0.006),分化程度越低表达率越低,而在正常肝组织、肝结节状增生和肝腺瘤中的表达较为接近,不具有统计学意义(P>0.05)。【结论】TTF-1有助于肝脏良、恶性病变的鉴别诊断,在肝细胞癌分化程度的判断上也具有一定的作用。
[Objective]To observe the expression of thyroid transcription factor-1（TTF-1） in benign and malignant disease of the liver,and to determine the implication of TTF-1 in differential diagnosis of benign and malignant disease of the liver.[Methods]The expression of TTF-1 was detected in 123 normal hepatic tissues,33 nodular hyperplasia of the liver,27 hepatic cell adenomas and 68 hepatocellular carcinoma by immunohistochemical SP method.[Results] TTF-1 cytoplasmic staining was observed in this study.The positive expression of TTF-1 was found in 89.4%（110 of 123） normal hepatic tissues,84.8%（28 of 33） nodular hyperplasia of the liver,85.2%（23 of 27） hepatic cell adenomas and 41.1%（28 of 68） hepatocellular carcinomas.TTF-1 positive expression in hepatocellular carcinoma was significantly lower than that in other three tissues（P=0.000）,and there was a significant correlation between the expression of TTF-1 and differentiated degree（P =0.006）.However,similar TTF-1 expression was shown among normal hepatic tissues,nodular hyperplasia of the liver and hepatic cell adenoma（P〉0.05）.[Conclusion] TTF-1 expression may be helpful for differential diagnosis of benign and malignant disease of the liver and judgement of differentiated degree of hepatocellular carcinoma.
出处
《医学临床研究》
CAS
2008年第11期1988-1990,共3页
Journal of Clinical Research
