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新型肝素结合细胞因子midkine的心血管作用 被引量：3

Effect of midkine,a newly heparin-binding cytokine,on cardiovascular functions
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摘要 Midkine (MK),a newly discovered heparin-binding growth factor,promotes growth,survival,and migration in various cells. Meanwhile,MK stimulates statistically significant forms in new arterioles and capillaries,causes vascular remodeling,prevents ischemia myocardial cells from injury via inhibiting apoptosis. MK also regulates the level of blood-fat. In general,MK plays key roles in cardiovascular diseases. Midkine （MK）, a newly discovered heparin -binding growth factor, promotes growth, survival, and migration in various cells. Meanwhile, MK stimulates statistically significant forms in new arterioles and capillaries, causes vascular remodeling, prevents ischemia myocardial cells from injury via inhibiting apoptosis. MK also regulates the level of blood - fat. In general, MK plays key roles in cardiovascular diseases.
作者 刘笑然 叶琳 马兰 唐朝枢
机构地区 海南医学院病理生理教研室 海南现代女子医院神经内科 北京大学第一医院心血管研究所
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2009年第11期2221-2224,共4页 Chinese Journal of Pathophysiology
基金 海南省自然科学基金资助项目(No.309064)
关键词 MIDKINE 血管生成 心血管系统 细胞凋亡 Midkine Angiogenesis Cardiovascular system Apoptosis
分类号 R54 [医药卫生—心血管疾病]
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参考文献17

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  • 2Matsuda Y, Talukder AH, Ishihara M, et al. Limited proteolysis by chymotrypsin of midkine and inhibition by heparin binding[J].Biochem Biophys Res Commun, 1996, 228(1) :176 - 181. 被引量：1
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二级参考文献12

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中国病理生理杂志
2009年 第11期

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