摘要
目的探讨曲伏前列素滴眼液(苏为坦)治疗难治性青光眼的疗效及安全性。方法难治性青光眼20例(20只眼),所有患眼均经1次以上手术未能有效控制眼压。对上述患者单独应用曲伏前列素滴眼液,每晚1次。用药后1个月及6个月在同一时段复查眼压1次,用药6个月后在同1天的8、11、14、16点钟分别检查眼压。观察用药前后的眼压、眼底及视野情况。结果用药前眼压24～33mmHg,平均27.8mmHg,用药1个月后眼压16～24mmHg,平均18.6mmHg,用药6个月后眼压15～25mmHg,平均18.3mmHg,治疗6个月后不同时间点眼压变化值比较差异无统计学意义(P>0.05)。眼底、视神经及视野未见明显进展。结膜充血是最常见副作用,见于本组所有眼。但仅3只眼达3级,其余均为1～2级,并随时间延长减轻。2只眼出现眼周皮下色素沉着,2只眼睫毛长长。未发现严重副作用,所有患者均未因副作用停药。结论曲伏前列素滴眼液能安全有效的降低难治性青光眼的眼压,其降眼压效果可靠,使用方便,患者依从性好,副作用小。
Obeject To evaluate the clinical effect and side effect of travoprost in treating patients with refractory glaucoma. Methods The eases were 20 eyes of 20 patients with refractory glaucoma. All eyes had at least one surgery and fail to control IOL. All patients with travoprost one drop at night once daily were studied. The observed signs included lOP （measured at the same time on the one and six month, and 8：00,11：00,14：00,16：00 at one day on six month）, visual acuity, visual field and complications. Results The IOP was 27.8 mm Hg before using travoprest （from 24 to 33 nan Hg）, One month after treatmem, the lOP was 18.6 mm Hg（ from 16 to 24 mm Hg ）. The last lOP was 18.3 mm Hg（ from 15 to 25 mm Hg）, After 6 months, IOP reductions had no obvious difference when measured at different time on the same day （ P 〉0.05 ） . There were no change of visual acuity ,optic nerve and visual field before and after using travoprost. All eases appeared conjunetival congestion, but they were 1-2 grade besides of 3 eyes were 3 grade, and all eyes eased with the extension of time, furthermore, 2 eyes had pigmentation on preorbit. Eyelashes of 2 eyes becoming rougher and longer. Except above described symptom , no other advere reaction both local and systemic were observed, and no eases interrupted the treatment because of the Side Effects. Conclusion It is demonstrated that travoprest is effective and safe in reducing IOP in refractory glaucoma. It is reliable and easy to use, and in the meanwhile, it had good patients compliance and small side effects.
出处
《临床眼科杂志》
2009年第5期427-429,共3页
Journal of Clinical Ophthalmology
关键词
曲伏前列素
苏为坦
青光眼
眼压
Travoprost
Travatan
Glaucoma
Intraocular pressure
