摘要
目的:探讨糖化血红蛋白(HbA1c)<7%的2型糖尿病(DM2)患者血糖波动与微血管并发症的关系。方法:对20例未合并微血管并发症和25例合并微血管并发症的HbA1c<7%的DM2患者应用动态血糖监测系统(CGMS)连续监测3d,计算平均血糖水平(MBG)、标准差(SD)、平均血糖波动幅度(MAGE)、最大血糖波动幅度(LAGE)、日间血糖绝对差(MODD)等指标,并测HbA1c、血压、血糖、血脂等。结果:HbA1c<7%合并微血管并发症组SD、MAGE、MODD、LAGE均显著高于HbA1c<7%未合并微血管并发症组(P<0.001～0.05)。结论:血糖波动是HbA1c<7%的DM2患者微血管并发症的危险因素,应积极控制血糖波动。
Objective To study the correlationship between blood fluctuation and microvascular complication in type 2 diabetes mellitus patients with glycosylated hemoglobin（HbA1c） levels 7%.Methods Forty five DM2 patients with blood HbA1c levels over 〈7% were examined with the continuous glucose monitoring system（CGMS） for 3 days.The patients were of two groups： 20 without micro-vascular complications and 25 with micro-vascular complications.The mean blood glucose（MBG）,standard deviation（SD）,mean amplitude of glycemic excursions（MAGE）,absolute means of daily differences（MODD） and largest amplitude of glycemic excursions（LAGE） in all these patients were calculated,with determination of blood HbA1C,glucose,lipids and BP of each individual.Results The parameters MBG-SD,MAGE,MODD,LAGE were significantly higher in the 25 patients with microvascular complication than those in the 20 patients without microvascular complication（P〈0.001～0.05）.Conclusion Glycemic fluctuation is a dangerous indepen-dent risk factor in the development of microvascular complication in type 2 diabetes mellitus patients with HbA1c〈7%.Active measures to strictly control glycemic excursions were desirable for treatment.
出处
《放射免疫学杂志》
CAS
2009年第4期388-390,共3页
Journal of Radioimmanology
关键词
糖尿病
2型
血糖波动
动态血糖监测
微血管并发症
diabetes mellitus type 2 glycemic excursion continuous glucose monitoring microvascular complication
