摘要
目的:探讨乳腺癌患者化疗前后血清瘦素(leptin)、肿瘤坏死因子-α(TNF-α)和可溶性肿瘤坏死因子受体(STNFR)水平的变化及临床意义。方法:应用放射免疫分析和ELISA对33例肺癌患者进行了化疗前后血清leptin、TNF-α和STNFR测定,并与35名正常健康人作比较。结果:在化疗前,乳腺癌患者血清leptin、TNF-α和STNFR水平非常显著地高于正常人组(P<0.01),经化疗后3个月与正常人组比较仍有差异(P<0.05)。结论:检测乳腺癌患者血清leptin、TNF-α和STNFR水平的变化对了解病情、观察疗效和预后均有重要的临床价值。
Objective To explore the changes of serum leptin,TNF-α and soluble TNF receptor（STNFR） levels in patients with breast cancer.Methods Serum leptin,TNF-α（with RIA） and STNFR（with ELISA） contents were measured in 33 patients with breast cancer both before and after chemotherapy as well as in 35 controls.Results Before chemotherapy,Serum levels of leptin,TNF-α and STNFR in the patients were significantly higher（P〈0.01） than those in controls.After chemotherapy for 3 months the serum levels of leptin,TNF-α and STNFR though dropped markedly,remained significantly higher than those in controls（P〈0.05）.Conclusion Serum leptin,TNF-α and STNFR levels were closely related to the diseases process and were of prognostic importance in patients with breast cancer.
出处
《放射免疫学杂志》
CAS
2009年第4期335-337,共3页
Journal of Radioimmanology
关键词
乳腺癌
瘦素
肿瘤坏死因子-α
可溶性肿瘤坏死因子受体
breast cancer leptin tumor necrosis factor-α（TNF-α） soluble tumor necrosis factor receptor（STNFR）
