摘要
目的探讨丝氨酸蛋白酶抑制蛋白3(SERPINA3)基因多态性与脑梗死的关系。方法采用聚合酶链反应(PCR)方法检测195例脑梗死患者和322名健康人(正常对照组)的SERPINA3基因rs4934位点的多态性。结果显性模型脑梗死组与正常对照组SERPINA3基因rs4934位点的基因型分布和等位基因频率差异无统计学意义(均P>0.05),但隐性模型(AA+AG vs GG)脑梗死组GG型比率显著高于正常对照组(P<0.05)。结论SERPINA3基因rs4934位点GG型在脑梗死患者中的比率高于正常人,SERPINA3基因多态性与脑梗死的发病有一定关系。
Objective To investigate the relationship between polymorphism of the serpin peptidase inhibitor 3 （SERPINA3） gene and cerebral infarction. Methods SERPINA3 gene polymorphism of 195 patients with cerebral infarction and 322 healthy controls （normal control group） were detected by polymerase chain reaction amplification. Results There was no significant difference of the SERPINA3 genotype distribution and allele frequency between cerebral infarction group and normal control group in the dominant model （ all P 〉 0.05 ） , but the rate of GG genotype in cerebral infarction group was significantly higher than that in normal control group （ P 〈 0. 05 ） in the recessive model （ AA ＋ AG vs GG）. Conclusions The frequence of GG genotype of SERPINA3 is higher in the patients with cerebral infarction than that in healthy subjects. The polymorphism of SERP1NA3 gene may be related with cerebral infarction.
出处
《临床神经病学杂志》
CAS
北大核心
2009年第5期325-327,共3页
Journal of Clinical Neurology
基金
中科院知识创新工程(KSCX2-YW-R-01)
