摘要
目的观察九香止泻片(又名秦香止泻肠溶片)对小鼠体内肠道常见致病菌的影响,探讨其治疗湿热泄泻的作用机制。方法分别腹腔注射小鼠致死量大肠杆菌、乙型副伤寒杆菌、痢疾杆菌3种不同细菌菌悬液制作腹泻感染动物模型,观察九香止泻片高、中、低3个不同剂量(以下简称九香高、中、低剂量组)及肠康片、诺氟沙星胶囊对感染小鼠模型的存活率、存活时间的影响。结果与模型组比,各药物组均可显著提高3种不同细菌感染小鼠模型的存活率、明显延长其存活时间,差异具有统计学意义(P﹤0.05),其中,诺氟沙星组、九香高剂量组均明显优于肠康片组,差异具有统计学意义(P﹤0.05),而九香中剂量组与肠康片组、九香高剂量组与诺氟沙星对感染模型小鼠存活率的提高及存活时间的延长相当。结论九香止泻片对腹腔注射致死量大肠杆菌、痢疾杆菌和乙型副伤寒杆菌等感染小鼠模型可明显提高其存活率,显著延长感染小鼠存活时间,并呈现一定的量效关系,表明其对感染模型小鼠具有较好的保护作用,对体内肠道常见致病菌具有较好抑制作用。
Objective To observe the effects of Jiuxiang Zhixie tablets on common intestinal bacteria and explore its mechanism in the treatment of damp-heat diarrhea. Methods Infectious diarrhea animal models were established by respective intraperitoneal injection with three different bacteria suspensions containing lethal dose of E. coli, bacterium paratyphosum B and Shigella bacteria. The effects of high, medium and low doses of Jiuxiang Zhixie tablets, Changkang tablets and Nortloxacin on the survival rate and survival time of infected mice were observed. Results Compared with model group, all drug significantly increased the survival rate, and prolonged the survival time （all P〈 0.05）. Compared with Changkang Tablets group, norfloxacin group and high dose Jiuxiang group were better （all P〈0.05）. The increase of survival rate and extension of survival time in medium dose Jiuxiang group were comparable with Changkang tablets group; comparable in high dose Jiuxiang group and norfloxacin group; the protective effect of Jiuxiang Zhixie tablets on infected mice and survival time had a certain dose-effect relationship. Conclusion Jiuxiang Zhixie tablets can significantly improve survival rate, prolong the survival time of the infected mice, which indicates that the tablet is very effective to protect the mice and inhibit the common intestinal bacteria in vivo.
出处
《湖南中医药大学学报》
CAS
2009年第5期32-34,47,共4页
Journal of Hunan University of Chinese Medicine
基金
湖南省教育厅重点项目(05A032)
关键词
九香止泻片
保护作用
秦皮
小鼠
泄泻
抑菌作用
Jiuxiangzhixie tablets
bacteriostasis
cortex fraxini
radix auckladiae
mice
diarrhea
