摘要
目的探讨小剂量阿立哌唑联合西酞普兰治疗抑郁症的疗效和安全性。方法采用随机开放对照研究,对52例抑郁症患者随机分为合用组与单用组,疗程6周,采用汉密尔顿抑郁量表(HAMD),临床疗效总评量表-病情严重程度(CGI-SI)评定疗效,副反应量表(TESS)评定安全性。结果合用组显效率73.08%,单用组53.85%,合用组明显高于单用组,合用组HAMD评分第1、2周末显著低于单用组(P<0.05),第6周评分有极显著性差异(P<0.01),副反应两组间无明显差异(P>0.05)。结论小剂量阿立哌唑联合西酞普兰治疗抑郁症,疗效明显优于单一应用西酞普兰治疗,起效快,副反应轻,安全性好。
Objective To explore the clinical efficacy and safety of citalopram combined with small--dose aripiprazole in the treatment of the patients with depression. Methods A total of 52 depression patients were randomly assigned to combination group and single group for 6 weeks. The clinical efficacy were evaluated by the hamilton depressive scale （HAMD） and the clinical global impression-severity of illness （CGI--SI）. Adverse effects were assessed by the treatment emergent symptom scale （TESS）. Results Effectivb rates were 73. 08% in the combination group and 53.85% in the single group. The former was significantly higher than the latter, compared with single group. The HAMD score lowered more significantly in the combination group at the end of the 1st week and at the end of the 2nd week （P〈0.05）, and did much more significantly in the combination group at the end of the 6th week （P〈0.01）. The adverse reactions of both groups were no significantly different（P〉0.05）. Conclusion Citalopram combined with small-dose aripiprazole had positive efficacy with taking effects rapidly,adverse reactions being milder and safety being higher, and could notably improve patients＇ compliance in the treatment of depression compared with single-use of citalopram.
出处
《中国健康心理学杂志》
2009年第10期1164-1165,共2页
China Journal of Health Psychology
