摘要
采用电纺工艺制备载豆腐果苷聚乙烯基吡咯烷酮纳米纤维膜.通过偏光显微镜确定电纺条件,利用扫描电镜对纤维膜表面形态进行观察;采用X-射线晶体衍射（XRD）和差示扫描量热分析（DSC）检测纤维膜中药物的存在状态,通过红外光谱分析药物与纤维基材之间的相互作用.结果表明载药纤维直径分布均匀（400-600 nm）、表面光滑无药物颗粒,药物与聚合物之间通过氢键作用、具有良好的相容性,XRD和DSC结果表明药物以无定形态高度分散于纳米纤维中,纤维膜中药物以＂聚合物控释＂机制在13.7 s左右完全溶解.
Drug-loaded nanofiber membrane was successfully prepared using electrospinning process with helicid as the poorly water-soluble model drug and polyvinylpyrrolidone（PVP K30） as the filament-forming matrix.Polarization microscopy（PM） and scanning electron microscopy（SEM） were taken to observe the morphology and structure of the nanofibers.Differential scanning calorimetry（DSC） and X-ray diffraction（XRD） were carried out to determine the physical status of the drug in the nanofibers.Fourier-transform infrared spectroscopy（FTIR） was conducted to characterize the interaction between the drug and the polymer.Results from the PM and SEM studies showed that the nanofibers had a very well uniform structure with a diameter of 400～600 nm and very smooth fiber surface.DSC and XRD results co-demonstrated that helicid lost its original crystal structure,the needle or long rod shape,but highly distributed in the nanofibers due to the forming of chemical complexes between the PVP K30 and the helecid molecules.FTIR spectra clearly showed that the main interactions between PVP and helicid were hydrogen bonding,which was formed between the carbonyl groups of PVP K30 and the hydroxyl groups of helicid and resulted in the firm existence of drug in the fibers.In vitro wetting and dissolution tests showed that the nanofiber membranes were able to absorb water and dissolve on the water surface in 13.7 s through the ＂polymer-controlled＂ mechanism,exhibiting great potential to provide strategies for resolving one of the most difficult problems in pharmaceutics——the dissolution and absorbance of poorly water-soluble drugs,and offer novel approaches for preparing oral fast dissolving drug delivery systems or fast acting dosage forms.
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2009年第11期1170-1174,共5页
Acta Polymerica Sinica
基金
London Metropolitan University-东华大学中英药用纺织品联合实验室
上海市科委基金(基金号08JC1400600)
中国博士后基金(基金号20080440565)资助项目
关键词
电纺
载药纳米纤维
聚乙烯基吡咯烷酮
速溶
难溶药物
Electrospinning
Drug-loaded nanofibers
Polyvinylpyrrolidone
Fast dissolving
Poorly water-soluble drug
