摘要
目的回顾性分析手术前行^18F-氟脱氧葡萄糖（fluorodeoxglucose，FDG）-正电子发射体层摄影术（position-emission tomography，PET）-计算机体层摄影术（CT）显像在头颈部鳞状细胞癌及其淋巴结转移诊断中的应用价值。方法分析20例术前行^18F-FDG-PET-CT显像的头颈部鳞状细胞癌患者，对其显像结果进行定性及定量评价。结果^18F-FDG-PET-CT正确显示了20例头颈部鳞状细胞癌肿块，其敏感度、特异性、阴性预测值和阳性预测值均为100％，肿块的平均标准摄取值（average standardized uptake value，SUVavg）为6.22±2.20；患者淋巴结转移的情况经^18F-FDG-PET-CT显像，其结果与病理和随访结果完全一致；以淋巴结为研究对象，统计分析转移淋巴结的SUVavg为3.97±1.25，^18F-FDG-PET-CT检测转移淋巴结的敏感性为51％（22／43）；特异性为97.7％（217／222）；假阳性率为2.3％（5／222）；假阴性率为49％（21／43）；阳性预测值为82％（22／27）；阴性预测值为91.2％（217／238）。结论^18F-FDG-PET-CT在判断头颈部鳞状细胞癌和淋巴结转移方面具有一定的临床价值；SUV作为评价FDG摄取的指标，在判断肿瘤良恶性方面具有一定的指导意义，但判断头颈部鳞状细胞癌淋巴结转移的SUV切峰值有待进一步研究。
Objective To evaluate ^18F-fluorodeoxylucose-position-emission tomography-computer tomography imaging （^18F-FDG-PET-CT） on head and neck squamous cell carcinoma（HNSCCA） and lymph node metastasis. Methods ^18F-FDG-PET-CT imaging of 20 patients with HNSCCA was evaluated retrospectively. Results All the primary tumors were correctly diagnosed by ^18F-PET-CT imaging and SUVavg of the primary tumors was （6.22±2.20）. All the sensitivity, specificity, positive predictive value and the negative predictive value were 100%. In detecting lymph node metastasis, the sensitivity was 51% , specificity 97.7% , false positive rate 2.3% , false negative rate 49% , positive predictive value 82%, and negative predictive value 91.2%. Conclusions ^18F-FDG-PET-CT imaging was valuable in detecting HNSCCA and lymph node metastasis. SUV was helpful for differential diagnosis between benign or malignant tumors but it needs further study to determine the cutoff SUV for differentiating lymph node metastasis.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2009年第10期601-605,共5页
Chinese Journal of Stomatology
