摘要
目的:探讨结直肠癌患者血清转化生长因子(TGF)-β1含量变化的临床意义。方法:采用ELISA法检测185例结直肠癌,46例结直肠腺瘤息肉、33例炎症性肠病患者和30位正常对照者及结直肠癌术后随访组、复发组血清TGFβ-1与CEA的含量,分析血清TGFβ-1含量与结直肠癌病理特征的关系。结果:结直肠癌组及肿瘤复发组TGFβ-1和CEA含量显著高于正常组(P<0.001);结直肠腺瘤息肉组及炎症性肠病组TGFβ-1含量亦明显高于正常组(P<0.05)而CEA含量无明显升高。术后各随访组TGFβ-1与CEA含量较术前显著降低(P<0.001)。结直肠癌组血清TGFβ-1含量与肿瘤分化程度、病理分期均呈显著正相关(P<0.01),与肿瘤大小相关(P<0.05)而与肿瘤部位无关。结论:血清TGF-β1可作为结直肠癌的具有一定临床价值的肿瘤标志物,有助于其临床诊断与评价、术后复发及高危对象的监测。
Objective： To study the change of serum transforming growth factor-beta1（TGF-β1） level in patients with colorectal cancer and its clinical significance.Methods： The serum levels of TGF-β1 and carcinoembryonic antigen（CEA） were measured by ELISA technique in 185 cases of colorectal cancer,46 colorectal adenoma,33 inflammatory bowel disease,and 30 normal controls.The relation between serum TGF-β1 level and clinical and pathologic features of colorectal cancer was evaluated.Results： The serum levels of TGF-β1 and CEA in colorectal cancer group and recurred colorectal cancer group were significantly higher than those in normal control group respectively（all P〈0.001）.The serum TGF-β1 level in colorectal adenoma group and inflammatory bowel disease group were also markedly higher than that in normal group（both P〈0.05）.The serum TGF-β1 levels in colorectal cancer group were positively correlated with pathologic features and not with the location of colorectal cancer.Conclusion： Serum TG...更多F-β1 level may be a valuable marker for colorectal cancer in the diagnosis and the monitoring of recurrence after resection in high risk population.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2009年第5期640-643,共4页
Medical Journal of Wuhan University
关键词
TGFΒ-1
CEA
血清
结直肠癌
Transforming Growth Factor-Beta1
Carcinoembryonic Antigen
Serum
Colorectal Cancer
