摘要
目的：探讨胸椎黄韧带骨化的病因。方法：对１４例胸椎黄韧带骨化（包括５例氟骨症）及１４例腰椎管狭窄症患者手术切除的黄韧带标本作病理研究；对患者血清及黄韧带采用雾化原子吸收法等方法测定钙、磷、镁、锌、铜、锰、钼、氟含量，取急性外伤性截瘫患者为对照。结果：（１）骨化黄韧带初期的病理改变与黄韧带退变性质类似；（２）除氟元素外，７种基本代谢元素在骨化与退变患者血清及黄韧带中含量均呈基本一致的变化规律；（３）非氟骨症骨化患者黄韧带中氟含量显著增高（Ｐ＜０．０１）。结论：本文证实胸椎黄韧带骨化发生于黄韧带退变的基础之上，但退变不直接导致骨化，元素氟是诱导退变黄韧带进一步骨化的重要诱因。
Objective: To study the etiology of ossifications of the ligamentum flavum(OLF) in the thoracic spine. Methods: Pathological study of ligamentum flavum was carried out in 14 patients with thoracic ossified ligamentum flavum, which included 5 fluorosis and 14 lumbar stenosis, meanwhile, the contents of Ca,P,Mg,Zn,Cu,Mn,Mo,F in ligaments and serums were detected by using atomic absorption spectrometry and fluoride selected electrode. Results: There was similar pathological changes between earlier period of ossification and degeneration of ligamentum flavum, also, there were similar changes of Ca,P,Mg,Zn,Cu,Mn,Mo in ligaments and serums of OLF and degenerations, however fluoride in the ligament was higher in non fluorosis OLF than in degenerations and normal controls. Conclusion: OLF was based on degeneration, but degeneration did not resulted in OLF directly, fluoride played an important role in the progressive changes of degenerative ligamentum flavum to ossification.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1998年第11期656-658,共3页
Chinese Journal of Orthopaedics
关键词
胸椎
腰椎
黄韧带骨化
椎管狭窄
病理学
元素
Thoracic vertebrae Ligamentum flavum Ossification,heterotopic Pathology Elements
