摘要
目的：研究癌基因ｂｃｌ－２及抑癌基因ｐ５３在子宫内膜癌发生、发展中的作用。方法：采用免疫组化ＡＢＣ法检测４９例子宫内膜癌中ｂｃｌ－２、ｐ５３基因蛋白的表达。结果：４９例子宫内膜癌中２６例ｂｃｌ－２表达阳性，占５３％；１２例ｐ５３表达阳性，占２５％。子宫内膜癌组织学分级Ｇ１、Ｇ２ｂｃｌ－２表达率（６６％）显著高于Ｇ３表达率（２１％，Ｐ＜００５），而Ｇ３ｐ５３表达率（４６％）显著高于Ｇ１、Ｇ２表达率（１７％，Ｐ＜００５），ｂｃｌ－２表达阳性与阴性者生存率统计无显著性差异，ｐ５３表达阳性者生存率显著低于ｐ５３表达阴性者。ｂｃｌ－２、ｐ５３表达与肌层浸润、手术分期无明显相关。结论：癌基因ｂｃｌ－２与抑癌基因ｐ５３可能在子宫内膜癌发生的不同阶段起作用，抑制细胞凋亡，促进肿瘤的发展与转归。
Objective:To study the overexpression of bcl-2 and p53 in endometrial carcinoma and its relationship to clinicopathological fectures and prognosis.Methods:Overexpression of bcl-2 and p53 were studied by immunohistochemistry ABC method in paraffin-embedded tissues in 49 women with endometrial carcinoma,and X 2 analysis and survival curves were determined by the Kaplan-Meier method.Results:Bcl-2 overexpression was observed in the majority(53%) of endometrial carcinoma,while p53 overexpression was in the minority(25%).Bcl-2 overexpression was found to be significantly higher in FIGO G 1 and G 2 than in G 3 tumors(P<0 05),while inversely,p53 overexpression was significantly higher in FIGO G 3 than in G 1,G 2 tumors(P<0 05).p53 overexpression was related to poor survival rates,while bcl-2 was not.Neither bcl-2 nor p53 overexpression in tumors correlated with invasion and stages.Conclusions:In the development of endometrial carcinoma,bcl-2 oncogene and p53 tumor-suppressor gene may correlate with the progression of the malignant process.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1998年第6期355-356,共2页
Chinese Journal of Practical Gynecology and Obstetrics
