摘要
15-脂加氧酶1（15-LOX-1）表达于人的多种组织细胞中，是催化不饱和脂肪酸代谢的关键酶之一，可以将亚油酸、花生四烯酸分别代谢为13-羟基十八碳二烯酸和15-羟基二十碳四烷酸，这些不饱和脂肪酸及其代谢衍生物是过氧化物酶增殖激活受体γ（PPARγ）的天然配体。研究发现，PPARγ以非活性状态在多种肿瘤组织中高表达，其与配体结合活化后，可诱导肿瘤细胞凋亡或者分化，发挥潜在的抗肿瘤作用。以15-LOX-1和PPARγ为靶向的肿瘤防治及其临床应用具有广阔前景。
15-lipoxygenase-1 （15-LOX-1 ）is expressed in varieties of human tissues. As one enzyme of the lipoxygenase family, 15-LOX-1 can metabolize linoleic acid and arachidonic acid to13-S-hydroxyoctadienoic acid and 15-hydroxyeicosatetraenoic acid respectively, which are natural ligands of PPARγ. The recent evidences indicate that PPARγ is highly expressed in some tumors with non-active state, which can suppress cell proliferation and induce apoptosis after combining with its ligands. PPARγ and its ligands could be valuable tools in the antitumors. By 15-LOX-1 and PPARγ-targeted research, it is possible to provide means of early detection and diagnosis of cancers and novel therapeutic options for treatment or prevention of tumors in the future.
出处
《国际肿瘤学杂志》
CAS
2009年第10期745-748,共4页
Journal of International Oncology
