摘要
15-脂氧合酶(15-LOX)是催化不饱和脂肪酸代谢的关键酶之一。人类中存有两型15-LOX:15-LOX-1和15-LOX-2,两者在催化性质、组织分布及肿瘤生物学功能上有所差异。近年来大量研究发现15-LOX在结肠癌、前列腺癌、食道癌等恶性肿瘤表达较正常组织降低,能够抑制肿瘤生长,并使其发生凋亡,在肿瘤发生发展中起着重要作用。以15-LOX为靶向的肿瘤防治及其临床应用具有广阔的前景。
As one enzyme of the lipoxygenase family, 15-lipoxygenase exerts important anticarcinogenic effects through the metabolism of polyunsaturated fatty acids. Two forms of 15-lipoxygenase occur in humans： 15-lipoxygenase-1 and 15-lipoxygenase-2. They are distinguished by their catalytic properties, tissue distribution and biological effects on tumor. Recent evidences indicate that the expression of 15-lipoxygenase was decreased in colorectal, prostate and esophageal cancer when compared with normal adjacent tissues. 15-lipoxygenase and its metabolites could inhibit the progression of cancer and induce their apoptosis. By 15-lipoxygenase-targeted research, it is possible to provide means of early detection and diagnosis of cancers and novel therapeutic options to treat or prevent cancers in the future.
出处
《国际内科学杂志》
CAS
2007年第6期343-346,共4页
International Journal of Internal Medicine
基金
福建省科技人才创新基金资助项目No2002J061
