摘要
目的探讨老年慢性肾脏疾病不同临床分期与血浆NT-proBNP的相关性。方法将确诊为慢性肾脏疾病的65岁以上老年患者350例按照慢性肾脏疾病分期分组,比较各组间NT-proBNP的水平。结果各组间血浆NT-proBNP的浓度差异有显著统计学意义(P<0.01);随访观察造成老年慢性肾脏疾病患者短期NT-proBNP浓度增加的因素主要包括感染(61.15%)、急性冠脉综合征或心力衰竭(29.49%)、急性肾功能不全(5.76%)、其他原因包括外科手术、肿瘤、应用非甾体类抗炎药等(3.6%)。结论在65岁以上老年慢性肾脏疾病患者中,随肾脏功能恶化,血浆NT-proBNP的浓度逐渐增加。而血浆NT-proBNP浓度短期增高与感染、急性冠脉综合征、心力衰竭、急性肾功能不全等多种因素有关。
Objective To study the NT-proBNP concentration in elderly patients with chronic kidney disease. Methods Three hundred fifty elderly patients with chronic kidney disease were divided into 4 stages by CKD stages,to compare NT-proBNP concentration of different stage of patients. Results The NT-proBNP concentration in every group were significantly different （P〈 0.01 ）. The causes of NT-proBNP concentration elevation in short-term include infection（61.15% ）,acute coronary syndrome or heart failure （29.5%）,acute renal failure （5.76%）, etc （3.6%）. Conclusions With the aggravation of renal function of 350 patients over 65 years older, NT-proBNP concentration is increased in same time. The NT-proBNP concentration increasing in short-term is related with infection, acute coronary syndrome ,heart failure, acute renal insufficient ,etc.
出处
《中华保健医学杂志》
2009年第5期359-361,共3页
Chinese Journal of Health Care and Medicine
