摘要
三唑类药物是目前抗真菌药的主流,特别是用于治疗深部真菌感染。1-(4-羟基苯基)-4-(4-硝基苯基)哌嗪是其重要的药物中间体,作为新一代抗真菌药关键中间体其的合成已成为研究热点。较全面地介绍了1-(4-羟基苯基)-4-(4-硝基苯基)哌嗪的各种合成路线。其合成途径基本上是先制备单N-芳基取代哌嗪,产物继续和适当的芳基卤化物进行N'-芳基化反应,得到1-(4-羟基苯基)-4-(4-硝基苯基)哌嗪。
As a key intermediate of triazoles, which are of great importance as antifungal medicines, 1-（4- hydroxylphenyl）-4-（4-nitrophenyl） piperazine can be synthesized in several routes, which were summarized in this review.
出处
《精细化工中间体》
CAS
2009年第5期8-12,22,共6页
Fine Chemical Intermediates
