摘要
以二乙醇胺为起始原料,经溴化环合"一锅法"合成1 (4 甲氧基苯基)哌嗪二盐酸盐,再经胺化、还原制得抗真菌药伊曲康唑的中间体1 (4 甲氧基苯基) 4 (4 氨基苯基)哌嗪,产品总收率35%。
The pharmaceutical intermediate 1 (4 Methoxyphenyl) 4 (Aminophenyl) piperazine was synthesized by three steps which are bromination cyclization in one pot from diethanoilamine and 4 aminoanisole firstly, alkylation secondly, and reduction lastly. The overall yield of the product is 35%.
出处
《精细化工中间体》
CAS
2003年第6期34-35,45,共3页
Fine Chemical Intermediates
