摘要
目的观察黄连解毒汤对高血压性脑出血患者血浆TNF-α、IL-6的影响,并阐明黄连解毒汤治疗高血压性脑出血急性期的作用机制,从而为脑出血急性期提供有效的脑保护方剂。方法将高血压性脑出血患者52例随机分为治疗组(A组)24例与对照组(B组)28例,另选取健康老年人30例为正常对照组(C组)。B组予以常规西医治疗,A组在B组基础上加用黄连解毒汤,两组均以2周为1疗程;A组及B组分别于治疗前及治疗后测血浆TNF-α及IL-6。结果高血压性脑出血患者TNF-α、IL-6显著高于正常对照者,治疗后A组TNF-α、IL-6与C组均无显著性差异;治疗后B组TNF-α、IL-6与C比较差异有显著性,A、B两组TNF-α、IL-6比较差异非常显著。A组在改善神经功能缺损方面显著优于B组。高血压性脑出血患者TNF-α及IL-6含量与神经功能缺损程度及血肿的大小呈正相关。结论TNF-α、IL-6可作为观察高血压性脑出血的病情监测指标,TNF-α和IL-6的含量反映病情严重程度,其含量越高则病情越重。黄连解毒汤对高血压性脑出血急性期的治疗有显著作用,能显著降低TNF-α、IL-6的含量,抑制白细胞对血肿周围脑组织的浸润,明显改善脑出血患者的病情。黄连解毒汤治疗高血压性脑出血安全有效,可为高血压性脑出血急性期提供有效的脑保护作用。
Objective： To investigate the effect of Huanglianjiedu Decoction on plasma TNF- α and IL- 6 in hypertensive cerebral hemorrhage patients and to evaluate the mechanism of Huanglianjiedu Decoction in acute period of hypertensive cerebral hemorrhage and to offer a kind of effective Chinese herbal medicine against cerebral hemorrhage in the acute stage. Methods： 52 patients with hypertensive cerebral hemorrhage were divided into treatment group （group A） and control group （group B）. Moreover, 30 health patients were selected into normal control group（C group）. Group B were given western medicine. Group A were taken Huanglianjiedu Decoction plus western medicine. Two groups took 2 weeks as one treatment course. Levels of TNF - α and IL - 6 were detected before and after treatments in two groups. Results： The levels of plasma TNF - α and IL - 6 of the hypertensive cerebral hemorrhage patients were markedly higher than those in group C. After therapy, there were not remarkable differences between group A and C. These differences also exist group B and C. Moreover, there were remarkably differences between group A and group B. Group A was much better than group B in decreasing the degree of neurological deficiency. Levels of plasmas TNF-α and IL-6 were positively correlated with the degree of neurological deficiency and the volume of hematoma. Conclusion： The Plasma TNF - α and the IL - 6 in plasma would be the indices of different degrees of hypertensive cerebral hemorrhage. Their levels could reflect the disease severity. The higher the levels are, the more serious the disease is. Huanglianjiedu Decoction is dominant in treating these patients who suffer the acute stage of hypertensive intracerebral hemorrage. It could decrease the levels of TNF - α and IL - 6 , inhibit the leukocyte chemotaxis and improve the conditions of patients. HuanglianjieDu Decoction is a safe and effective Chinese herbal medicine against hypertensive intracerebral hemorrhage. It would provide protective effect for tre
出处
《中国中医急症》
2009年第11期1762-1764,1772,共4页
Journal of Emergency in Traditional Chinese Medicine
关键词
颅内出血
高血压
肿瘤坏死因子-α
白细胞介素-6
黄连解毒汤
Cerebral hemorrhage
Hypertensive cerebral
Tumor necrosis factor- α
Interleukin -6
Huanglian- jiedu Decoction
