摘要
应用链菌素亲和素-过氧化物酶（LSAB）免疫组织化学技术对49例膀胱肿瘤石蜡切片bcl-2原癌基因蛋白的表达进行研究。结果显示，在各级（期）膀胱肿瘤中均有bcl－2基因表达。随着肿瘤分级、分期的增加，bcl－2基因表达增多，但无显著性差异（P＞0．05）。在＞50岁以上患者中，bcl-2基因表达率明显高于≤50岁者（P＜0．05）。虽然在复发肿瘤和多发肿瘤及男性患者bcl-2基因表达有增加趋势，但其间无显著性差异（P＞0．05）。认为除年龄因素外，bcl-2基因表达水平在肿瘤组织学分级、分期、初发或复发、单发或多发及性别之间无明显的相关性。
Using an LSAB immunohistochemical method expression of bcl-2 oncoprotein wasinvestigated in paraffin sections of 49 patients with the bladder tumours,including 8 cases of transitionalcell papilloma. It was found that bcl-2 expresced in all grade and stage tumors. Generally,bcl-2 expressed more frequently in higher grade and stage tumors than that in lower grade and stage,expressed bcl-2 with a great frequency than the tumors with,but the difference failed to achievestatistic significance (P＞0. 05). The incidence of bcl-2 expression in cases of＞50 years old wassignificantly higher than in patients under age 50 (P＜0. 05),and there was a trend of increasingbcl-2 expression with recurrent and multiple tumors and male cases,but it did not reach statisticalslngificance (P＞0. 05). This study shows that no relationship exists between tumors grade,stage, initial/recurrence,single/multiple,sex and level of bcl-2 expression except the age.
出处
《临床泌尿外科杂志》
1998年第11期506-508,共3页
Journal of Clinical Urology
关键词
BCL-2基因
膀胱肿瘤
基因表达
LSAB
bcl-2 gene Bladder tumor Immunohistochemistry Transitional cell cancer
