摘要
目的：为研究强化环境训练对低碘鼠学习能力、脑ＤＮＡ及胆碱能神经元相关酶类活性的影响。方法：自缺碘大鼠生后２５天起给予强化环境训练，１５天后测定其学习能力、各脑区ＤＮＡ含量及胆碱能神经元相关酶活性。结果：训练低碘鼠与非训练低碘鼠比较，学习能力，海马、小脑的ＣＨＡＴ活性，大脑皮层、海马的ＡＣＨＥ活性和不可提取ＡＣＨＥ活性百分比，均有明显增高，但仍低于正常对照水平。结论：强化环境训练虽对各脑区神经细胞数目无明显影响，但对神经元的功能活动和精细结构的重建可能具有积极作用，使学习能力得以提高。
Objective:To clarify the effect of intensify environment training on learning capacity,cerebral DNA and enzymic activity of cholinergic system in low iodine rats.Methods:The rats with 25 days old,fed by low iodine diet,were shifted into a special box and were broadcasted the light music, 60min,four times/per day.After 15 days,the learning capacity as well as DNA,choline acetyltransferase(CHAT),acetylcholinesterse(ACHE) activity in brain were measured.Results:Comparison was made between experimental rats and without intensify environment training rats.In experimental rats,the learning capacity,cerebral CHAT,ACHE or non-extractable ACHE activities were higher than those of control rats.But they still didn't reach the normal levels.Conclusion:It shows that intensify environment training may raise or improve the learning capacity,functional activities of central cholinergic system in low iodine rats.However,it didn’t increase the numbers of nervous cells.
出处
《中华理疗杂志》
1998年第5期261-264,共4页
Chinese Journal of Physical Therapy
关键词
强化环境训练
大鼠
学习
胆碱能神经元
克汀病
Reinforcement,social Rats Iodine Helplessness,learned DNA Choline acetyltransferase Cholinesterase
