摘要
目的:观察乙醇酸注射对大鼠肝脏的局部坏死作用,并与无水酒精注射所导致的鼠肝坏死程度作比较。方法:对鼠肝局部注射一系列浓度的乙醇酸和无水酒精后,测量大鼠肝脏坏死的平均直径并对其进行病理组织学考察。结果:乙醇酸可引起大鼠肝脏局部坏死,且与周围分界清晰。由浓度为5%、10%、15%、20%、30%、40%和50%的乙醇酸所导致的鼠肝坏死区域最大横截面的平均直径均比由无水酒精导致的大(P<0.05),且光镜也进一步证实了乙醇酸对鼠肝所产生的更完全的坏死作用。结论:乙醇酸可引起大鼠肝脏局部较完全坏死,有望作为一种新的化学灭活剂,代替无水酒精局部注射治疗肝癌。
Objective： To observe local necrosis of rat livers resulted from glycolic acid injection and compare necrosis effects resulted from glycolic acid injection and ethanol injection. Methods ： After injections of a series of concentrations of glycolic acid and ethanol into rat livers, the mean diameters and the pathologic histology examinations of coagulation necrosis in rat livers were detected. Results：Necrosis occurred around the injection site of glycolic acid. The mean diameter of the necrotic area caused by 5%, 10% , 15%, 20% ,30% ,40% and 50% glycolic acid was significantly larger than that caused by ethanol （ P 〈 0.05 ）, and pathohistology confirmed that the necrosis was more serious in the former group. Conclusion：Glycolic acid could cause local necrosis of liver, and might be used in clinical practices in the future as a substitute of ethanol for the treatment of liver cancer.
出处
《药学实践杂志》
CAS
2009年第5期337-339,372,共4页
Journal of Pharmaceutical Practice
关键词
乙醇酸
无水酒精
肝坏死
大鼠
glycolie acid
ethanol
hepatic local necrosis
rats
