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腺苷酸激活蛋白激酶在脂肪组织中的作用 被引量:2

The function of adenine monophosphate activated protein kinase in adipose tissue
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摘要 腺苷酸激活蛋白激酶(AMPK)是细胞和机体能量代谢的主要调节器。组织缺氧、低血糖、禁食和运动可以激活脂肪细胞中的AMPK。AMPK活化后能通过磷酸化下游信号分子,刺激能量生成途径(葡萄糖转运,脂肪酸氧化)关闭能量消耗的途径(脂肪、蛋白质、糖类的生成)。现在已经明确脂肪组织不仅是能量储存的场所,也在能量平衡以及其它很多过程中发挥作用。研究AMPK与脂肪组织的关系,将为AMPK作为防治肥胖的新靶点提供可靠的理论基础和应用依据。 The adenine monophosphate (AMP) activated protein kinase (AMPK) is a major regulator of energy metabolism at both the cell and whole body level. The activation of AMPK stimulates pathways which increase energy production (glucose transportation, fatty acid oxidation ) and switches off pathways which consume energy (lipogenesis, protein synthesis, gluconeogenesis). And adipose tissue is not only the place for energy storing, but also plays a critical role in energy homeostasis and many other processes.
出处 《国际内科学杂志》 CAS 2009年第10期601-605,共5页 International Journal of Internal Medicine
关键词 腺苷酸激活蛋白激酶(AMPK) 脂肪组织 脂肪细胞 Adenine monophosphate activated protein kinase Adipose tissue Adipocytes
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