摘要
作者应用冠醚色层柱，以ＫＨ２ＰＯ４为流动相，再在流动相中加入辛胺，并用乙腈调节辛胺浓度的方法，研究了放射性药物１１１Ｉｎ－ＤＴＰＡ络合物和未反应的游离ＤＴＰＡ的容量因子与流动相碱性离子对试剂浓度及其ｐＨ值的关系．结果表明，两者均随流动相中碱性离子对浓度的增加而增大，而随流动相中ｐＨ值的增大而下降，较好地解决了放射性药物１１１Ｉｎ－ＤＴＰＡ络合物和游离ＤＴＰＡ的分离和测定问题，为脑显象剂——放射性药物１１１Ｉｎ－ＤＴＰＡ络合物的研制。
The relation between capacity factor and basic ion pairing agents concentration on the 111 In DTPA complex and free DTPA is studied with ion pair chromatography in nor mal phase mode.The relation between capacity factor and pH value of the mobile phase on the 111 In DTPA complex and free DTPA is studied.The optimum conditions are derived from systematic study of the effect of various mobile phase parameters on retention characteristics of 111 In DTPA complex and DTPA.The separation and determination between the unreacted free DTPA and radiopharmaceutical 111 In DTPA complex is carried out with the difference of both the retention time.The unreacted free DTPA contained generally is 20～40μg in the finished 37×10 6Bq/mL rdiophamaceutical 111 In DTPA complex.
出处
《四川大学学报（自然科学版）》
CAS
CSCD
北大核心
1998年第5期725-728,共4页
Journal of Sichuan University(Natural Science Edition)
基金
四川省科委资助
关键词
DTPA
放射性药物
容量因子
铟络合物
Indium (In),diethylenetriaminepentaacetic acid (DTPA),radiopharmaceutical complex,capacity factor,basic ion pairing agents
