摘要
目的比较精神分裂症、抑郁症患者血浆瘦素及总胆固醇水平。方法48例首发精神分裂症患者，用简明精神病评定量表（BPRS）、阳性和阴性症状量表（Positive and Negative Syndrome Scale，PANSS）量表评定，45例首发抑郁症用汉密顿抑郁量表（HAMD-24）进行评定，32例体检职工为对照组，所有入组对象服药前测定体质量指数、血浆瘦素和总胆固醇。结果（1）正常对照组[（4．8±0．9）mmol／L]总胆固醇均高于抑郁症组[-（3．7±1．0）mmol／L]及精神分裂症组[（3．4±0．9）mmol／L；P〈0．05～0．01]，而抑郁症组与精神分裂症组之间的差异无显著性（P〉0．05）；正常对照组血浆瘦素[（13．4±6．7）g／L]高于抑郁症组[（9．6±4．2）g／L]及精神分裂症组[（5．8±3．4）g／L；P〈0．05～0．01]，抑郁症组高于精神分裂症组（P〈0．05）。（2）3组的血浆瘦素硬总胆固醇均与BMI呈正相关（r=0．48～0．63；P〈0．01）；精神分裂症组的血浆瘦素和总胆固醇与PANSS阳性分、BPRS分均呈显著负相关（r=-0．38～-0．50；均P〈0．01）；抑郁症组的血浆瘦素、总胆固醇与HAMD分呈显著负相关（r=-0．37～-0．41；P〈0．05～0．01）。结论精神分裂症和抑邰症患者的血浆瘦素及总胆固醇水平的降低独立于药物治疗和BMI改变之外，其在精神障碍中的重要病理生理学机制值得进一步深入探讨。
Objective To investigate the level of plasma leptin and total cholesterol of first-episode schizophrenic and depressive patients. Methods 48 first-episode schizophrenic patients were assessed by Brief Psychiatric Rating Scale（BPRS） ,Positive and Negative Syndrome Scale（PANSS） ,45 depressive patients were assessed by Hamilton Depression Scale（ HAMD-24 ） , and 32 individuals who took part in health examination were selected as health control group. Body mass index（BMI） , plasma leptin and total cholesterol were measured before taking pills. Results ①The total cholesterol of health control group[ （4.8 ± 0.9）mmol/L] was higher than depressive group[ （3. 7 ± 1.0 ） mmol/L] and schizophrenic group [ （ 3.4 ± 0.9） mmol/L ] （P 〈 0.05 - 0.01 ）, but there was no significant difference between depressive group and schizophrenic group（P 〉 0.05 ） ; the plasma leptin of health control group[ （ 13.4 ± 6.7 ） g/L ] was higher than depressive group [ （ 9.6 ± 4.2 ） g/L ] and schizophrenic group[ （5.8 ±3.4） g/L] （P〈0.05 - 0.01 ） ,and schizophrenic group was obviously higher than depressive group（ P〈 0.05 ）. （2） The plasma leptin and total cholesterol of the three groups were positively correlated with BMI （r = 0.48 -0.63, P〈 0.01 ） ; the plasma leptin and total cholesterol of the schizophrenic group were negatively correlated with PANSS positive score,PANSS seore（r = -0.38 - -0.50, P 〈 0.01 ） ; the plasma leptin and total cholesterol of the depressive group were negatively correlated with HAMD seore（r = -0.37 - -0.41, P 〈 0.05 0.01）. Conclusion The degradation of plasma leptin and total cholesterol of the schizophrenic and depressive patients were independent of medication and BMI,and the pathophysiologic mechanism in mental disorders deserve further research.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2009年第10期888-890,共3页
Chinese Journal of Behavioral Medicine and Brain Science
