摘要
目的观察运动前区(PMA)在动词生成任务fMRI试验中的激活情况,探讨其在语言表达功能中的可能作用。方法对23名受试者接受fMRI试验。试验任务为组块设计的动词生成任务:对照内容为黑色屏幕中心呈现的白色"+";刺激任务为生成动词,要求受试者根据给出的单字名词,组成一个相关的动词词语。采用SPM2软件进行数据后处理,采用单样本t-检验的组分析方法获得平均脑激活图,观察PMA激活情况。结果11名符合试验要求的受试者的数据列入组分析,脑激活区包括Broca区、右侧额下回后部、双侧PMC、双侧SMA、左侧顶后皮层、右侧丘脑、左侧基底节区、右侧小脑半球和右侧颞叶后部。全脑最强激活区为左侧PMA。结论PMA在动词生成任务中具有重要作用,可能涉及语音处理、想象运动、词语提取和信息的高级调控等多个方面。
Objective To evaluate the activation of premotor area （PMA） in verb generation task, and to discuss the possible function of PMA in language expression. Methods Block-designed fMRI with verb generation task was performed on 23 subjects with GE 1.5T MR Scanner. During the test, the subjects were asked to generate a verb based on a given noun word. The white ＂＋＂ appeared on the center of the black screen was used as control. The fMRI data were processed with SPM 2. Group analysis was performed with single sample t-test. Average mapping was obtained and overlapped onto standard MNI template. Activation of the PMA was analyzed. Results The fMRI data of eleven subjects were selected for group analysis after head motion effect was ruled out. Average mapping showed activation in the Broca＇s area, posterior part of the right inferior frontal gyrus, bilateral PMA and supplemental areas （SMA）, left posterior parietal cortex, right thalamus, left basal ganglions, right cerebellum, and posterior part of the right temporal lobe. The area with the greatest activated intensity in the brain was the left PMA. Conclusion PMC is important in verb generation and may be responsible for voice processing, motor imagery, word extracting as well as advanced regulation of information.
出处
《中国医学影像技术》
CSCD
北大核心
2009年第10期1769-1772,共4页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金(30700193)
关键词
运动前区
动词生成
磁共振成像
Premotor area
Verb generation
Magnetic resonance imaging
