摘要
目的:观察动词生成任务过程中的fMRI脑激活情况,分析各脑激活区在动词生成任务中的作用。方法:对23例正常志愿者进行组块设计的动词生成任务fMRI,试验中要求被试者根据给出的单字名词,组成一个相关的动词词语。fMRI扫描采用GE公司1.5T磁共振仪。采用SPM2软件对试验数据进行预处理和统计分析,将激活区叠加于MNI标准模板脑,观察有统计学意义的体素所在的脑区及其MNI坐标,记录激活区的激活强度。结果:动词生成任务的主要激活区包括:Broca区和左侧岛叶部分皮层;右侧额下回后部和部分岛叶皮层;双侧运动前区(以左侧为主);双侧辅助运动区;左侧扣带回前部;左侧顶后皮层;两侧丘脑;两侧基底节区;双侧小脑半球(以右侧为主);左颞下回;两枕叶也见散在激活,但强度较弱。结论:动词生成任务可有效激活与语言输出功能有关的相关脑区,这些脑区可能是语言输出功能的神经网络基础。
Objective： To observe the activated areas during performing verb generation tasks, and analyze the possible funetion of activated areas in expressive langu age. Methods： Twenty-three subjects were recruited in this study, all them received block-designed fMRI with verb generation tasks. The subjects were asked to generate a verb based on a given noun word during experiment. GE 1.5 T MR Scanner was used to obtain fMRI data with GRE-EPI. SPM2 was used to process fMRI data. Finally, activated mapping was overlapped onto standard MNI template.Locations, MNI coordinate and activated intensity of the brain areas were recorded. Results： Verb generation task mainly activated Broea＇s area, bilateral PMC and SMA, bilateral insular lobes, anterior part of the left cingulated gyrus, left posterior parietal cortex , bilateral thalamus and basal ganglions, bilateral cerebellum with right prominence, and bilateral occipital lobes. Conclusion： Verb generation is effective tasks for detecting brain areas related to expressive language with functional MRI. All these activated areas form a complex neural network for expressive language.
出处
《天津医科大学学报》
2009年第3期351-353,397,共4页
Journal of Tianjin Medical University
基金
国家自然科学基金青年科学基金资助项目(30700193)
