摘要
作者应用免疫组化技术,检测47例胰腺癌组织中nm23基因产物NDPK的表达,以探讨nm23基因与胰腺癌病理特征及生物学行为的关系。结果:47例胰腺癌NDPK阳性率为59.6%(28/47)。组织学为Ⅰ级的病例NDPK阳性率(73.3%)明显高于Ⅲ级者(41.7%,P<0.05);无淋巴结转移者NDPK阳性率高于有转移者(分别为80.8%和33.3%),有非常显著性差异(P<0.01);NDPK表达阳性者术后1年生存率为25.0%,而阴性者为0,有显著性差异(P<0.05);NDPK阳性率与胰腺癌病理类型无关(P>0.05)。结果表明:nm23基因对胰腺癌转移具有抑制作用,NDPK表达状况可反映胰腺癌的分化程度及生物学行为。
The expression of nm23 NDPK in 47 pancreative carcinoma was studied immunohistochemically,positive staining showed in 28 cases (59.6%).There was no significant correlation between the expression of nm23 NDPK and histopathologic classification.However,negative correlativity was observed between nm23 NDPK expression and lymph node metastasis and histologic grading(P<0.05).Expression of nm23 NDPK was positively associated with postoperative survival(1 year,P<0.05).These results suggest that nm23 gene play an important role in inhibition from metastasis of pancreative carcinoma, and may serve as a indicator to predict the prognosis of patients with pancreative carcinoma.
出处
《实用癌症杂志》
1998年第1期9-10,共2页
The Practical Journal of Cancer
关键词
胰腺肿瘤
NM23基因
二磷酸核苷激酶
Pancreative carcinoma nm23 gene Nucleosidediphosphokinase(NDPK)