摘要
目的了解血浆和脑脊液5-羟色胺(5-HT)含量的降低与脑卒中后抑郁症(PSD)的关系。方法检测30例PSD及30例对照组的血浆和脑脊液5-羟色胺含量,并进行对比分析。结果PSD患者血浆和脑脊液5-羟色胺含量明显低于对照组(P<0.01)。但在不同的时间脑脊液和血液的5-羟色胺的水平无明显波动(P>0.05)。结论血浆和脑脊液5-羟色胺含量的降低在PSD发病机制中起着重要作用。
Objective To understand the relationship between poststroke depression（PSD） and the level of 5-hydroxytryptamine （5-HT） in plasma and cerebrospinal fluid（CSF） of cerebral stroke patients. Methods The levels of 5-HT in plasma and CSF were neasured in PSD group（n= 30） and healthy control group（n=30）,and the results were compared and analyzed. Results The levels of 5- HT in plasma and CSF were significantly higher in PSD group than those in healthy control group（P 0.01）. However,the levels of 5-HT in plasma and CSF didn＇t fluctuate in different time points（P〉 0. 05）. Conclusion The decreased level of 5-HT in plasma and CSF may play an important role in pathogenesis of poststroke depression.
出处
《国际检验医学杂志》
CAS
2009年第10期967-968,共2页
International Journal of Laboratory Medicine
关键词
脑血管意外
抑郁症
血清素
Cerebrovascular Accident
Depressive Disorder
Serotonin
