摘要
为了探讨苍脂颗粒剂治疗脾胃病的胃粘膜保护作用，采用利血平模拟的大鼠脾虚证及亚急性阿斯匹林胃粘膜损伤模型，测定其对非蛋白质流基物质（NPSH）、谷胱甘肽过氧化物酶（GSH－px）、过氧化氢酶（CAT）、超氧化物歧化酶（SOD）及血浆过氧化脂质（LPO）等具有胃粘膜细胞保护作用物质的含量或活性的影响。结果显示，苍脂颗粒剂可以明显改善脾虚伴慢性胃粘膜病变大鼠及亚急性阿期匹林胃粘膜损伤大鼠的粘膜损伤程度，显著提高胃粘膜NPSH（F＜0．01）、GSH-px（P＜0．01）等细胞保护物质的水平．提示苍脂颗粒剂具有一定的胃粘膜细胞保护作用。
To research the gastric mucosal cytoprotective effect of the Cangzhi powder, Using the rat models with deficiency spleen and gastric mucosa injury induced by reserpine and aspirin we respectively detected the content and activity of the NPSH, GSH-px, CAT, SOD and LPO before and after Cangzhi powder treatment. The results showed that Cangzhi powder significantly decreased the degree of chronic mucosal injury accomanied by spleen deficiency and subacute mucosa lessions in rats. Meanwhile, it increased the levels of gastric mucosal cytoprotective factors such as NPSH(P＜0.01)and GSH-px(P＜0.01).It is suggested that Cangzhi powder posessed the protective ffect on gastric mucosa.
基金
北京市科委基金!(No.854670600)
