摘要
提出了裸ＧＣＥ不需任何处理测定甲氰咪胍的方法．浓度在３×１０－７～６×１０－５ｇ／ｍＬ范围内与峰电流呈线性关系，ＲＳＤ为２．２％（ｎ＝１０）．，回收率为９６％～１０２％．该方法操作简便快速，大多数金属离子和多种有机生化物质不干扰测定，方法用于片剂和加标尿样中甲氰咪胍的测定与药典方法对照，获得满意结果，并对电极反应进行了初步探讨．
The Voltammetric behaviour of a histamine H 2 antagonist inhibits secretion drug cimetidine was investigated by linear sweep,differential pulse,cyclic voltammetry at a glassy carbon electrode. In a medium of 0.1mol/L NaOH,an oxidative peak of cimetidine is obtained. The peak potential is at about +0.75V(vs.Ag/AgCl).The peak current is linearly increased with the concentration of cimetidine over the range of 3×10 -7 ～6×10 -5 g/mL. The method has been used for the direct determination of cimetidine in tablets. The average recoveries of cimetidine in urine samples are in the range of 96%～102%. The mechanism of the electrode reaction has been discussed.
出处
《分析科学学报》
CAS
CSCD
1998年第4期301-304,共4页
Journal of Analytical Science
关键词
甲氰嘛胍
裸玻碳电极
伏安法
分析
Cimetidine, Glassy carbon electrode, Voltammetry.
