摘要
毒草碱受体（M受体）是体内重要的G蛋白偶联受体之一，有M1～M5五种药理学亚型，各亚型在体内的分布和功能不同，受体蛋白结构和信号转导机制也有差异。对M受体、相关选择性药物及受体一配体作用位点的研究，将为设计以M受体各亚型为靶标的选择性药物提供帮助，对临床治疗多种M受体功能紊乱的疾病，如阿尔茨海默病等具有重要意义。
Muscarinic receptors （M receptors）, the important members of G protein-coupled receptors, comprise five subtypes M1-M5. Each subtype has different distribution and biological function in vivo, and their protein structures and signal transduction pathways are distinct as well. Studies on M receptors, related selective drugs and receptor-ligand binding sites could provide some information helpful to the design of selective compounds targeting single M receptor subtype. This is very important to develop clinical therapy for various diseases related to M receptors system dysfunction, such as Alzeimer＇s disease and so on.
出处
《国际药学研究杂志》
CAS
2009年第5期355-361,共7页
Journal of International Pharmaceutical Research
关键词
毒蕈碱受体
胆碱能药物
亚型选择性
muscarinic receptors
cholinergic drugs
subtype selectivity
