摘要
目的:探讨微生态制剂联合鼻饲喂养治疗极低出生体重儿的临床疗效。方法:将48例极低出生体重儿随机分为两组。对照组(23例)间断鼻饲注入喂养,起始每次奶量2 mL/kg,每3 h 1次,每天递增2 mL/kg。治疗组(25例)在间断鼻饲喂养基础上给予微生态制剂0.5 g/次,2次/d,鼻饲注入。所有极低出生体重儿均同时进行部分静脉营养,直至达到完全胃肠道喂养时间。结果:治疗组黄疸消退日龄(13.32±1.63)d,对照组(14.96±1.46)d,t=3.64,P<0.01;达到完全肠道喂养时间治疗组为(17.84±1.28)d,对照组为(20.04±1.5)d,t=5.37,P<0.01。发生喂养不耐受治疗组3例,对照组10例,两组比较差异有统计学意义(χ2=6.01,P<0.05)。结论:极低出生体重儿进行胃肠道喂养同时补充微生态制剂,在减少喂养不耐受发生率、促进黄疸消退、早日过渡到全胃肠营养方面有积极作用。
Objective： To study the efficacy of microecologicals combined with nasogastric feeding in very low birth weight infants （VLBWI）. Methods： Fourty-eight VLBW infants were randomly divided into a control group （ n = 23 ） and a therapy group （ n = 25 ）. Infants in the control group received intermittent nasogastric feeding every 3 hours, with starting feeding volume at 2 mL/kg which was increased by 2 mL/（kg · d）. Following the same treatment applied in the control group, the infants in the therapy group received oral microecologicals additionally. All the VLBW infants received partial parenteral nutrition until they achieved full enteral feeding. Results： The time of neonatal jaundice resolving and full enteral feeding in the therapy group was shorter than that in control group [ the therapy group was （ 13.32 ± 1.63） d and （ 17.84 ± 1.28） d; the control group was （ 14.96 ± 1.46） d and （20.04 ± 1.5） d, P 〈 0.01 ]. There was significant difference at the incidence of feeding intolerance （χ^2 =6.01, P 〈0.05）. Conclusions： Microecologicals combined with intermittent nasogastric feeding is a good way to help VLBW infants to decrease the incidence of feeding intolerance, promote jaundice extinction and achieve total enteral nutrition earlier.
出处
《儿科药学杂志》
CAS
2009年第5期22-24,共3页
Journal of Pediatric Pharmacy
关键词
极低出生体重儿
微生态制剂
喂养
Very low birth weight infants
Microecologicals
Feeding
