摘要
Rab蛋白属于Ras超家族,存在于所有的真核生物。目前在人类已发现约70种Rab蛋白,每种Rab蛋白又可以作用于不同的效应因子,并受到不同上游因子的调控,组成一个调节网络,在细胞内囊泡的形成、运输、粘附和聚集中起重要作用。随着研究的深入,人们发现一些Rab蛋白及其效应因子在信号传导中也起重要作用,并进一步影响细胞的增殖、分化,甚至凋亡。
The Rab family belongs to the Ras superfamily of small GTPases, members of which are found in all eukaryotes, including yeast, plants and mammals. There are almost 70 Rab proteins and Rab-like proteins in human cells. Each Rab protein can regulate different effectors and be regulated by some upstream effectors, so as to confer directionality to vesicle budding, vesicle delivery, vesicle tethering, and fusion of the vesicle membrane with that of the target compartment. Recently, several studies have demonstrated some of Rab proteins and their effectors were potential regulators of intracellular signaling pathways, and directed a variety of cellular processes, including cell growth, differentiation, proliferation, and apoptosis.
出处
《生命的化学》
CAS
CSCD
北大核心
2009年第5期678-682,共5页
Chemistry of Life
基金
上海市教委基金(No06BZ032)
上海市科委基金重点项目(No0752nm028)资助
