摘要
目的：为了探讨同安县原发性肝癌（PHC）高发的主要危险因素。方法：应用流行病学调查研究的方法，开展了1：2配对的PHC危险因素病例一对照、ELISA法的高危人群筛检、HBV＄染与PHC关系的前瞻性研究。结果;HBsAg携带率病例组高于对照组，抗一HBs阳性率病例组低于对照组;HBsAg、AFP阳性率男性高于女性，抗-HBs阳性率男性低于女性;HBsAg（十）者的肝癌发生率高于HBsAg（-）者，HBsAg（十）、HBeAg（＋）者的PHC发生率低于HBsAg（十）、AFP（十）者的PHC发生率，与HBsAg（＋）者无显著性差异。结论;在同安，HBsAg（＋）与PHC的发生有病因学的相关关系，HBsAg携带者的AFP阳性状态更增加了发生PHC的危险性。
OBJECTIVE To study the main risk factors of high incidence of PHC (primary hepatocellular carcinoma) in Tongan, Fujian. METHODS The case-control study by 1: 2 matching, mass screen with high risk by ELISA, prospective observation of HBV infection and PHC. RESULTS In case group, the HBsAg positive rate was higher than that in control group. But the anti-HBS was lower. In male, the HBsAg, AFP positive rates were higher than that in female. But anti-HBs positive rate was lower. The PHC incidence in population with HBsAg positive was higher than that in HBsAg negative. But it was lower in both HBsAg and HBeAg positive than that in both HBsAg and AFP positive and was no significant difference comparing the former with that in HBsAg positive. CONCLUSION There is a relationship between HBsAg and PHC in qtiology in Tongan. And there is more risk of causing PHC if HBsAg and AFP are positive simultaneously.
出处
《海峡预防医学杂志》
CAS
1998年第3期1-3,共3页
Strait Journal of Preventive Medicine
基金
福建省"八五"重点科技攻关项目
关键词
HBV病毒感染
流行病学
肝癌高发区
HBV infection, primary hepatocellular carcinoma, epidemiology
