摘要
目的:观察应用盐酸羟考酮控释片(TM)口服和经直肠不同途径给药对中重度癌性疼痛的疗效和不良反应。方法:61例伴有中重度疼痛的癌症患者随机分A组(口服TM)31例和B组(经直肠应用TM)30例。分别应用≤60m g/d和>60 m g/d两个剂量组,对TM的不同程度疼痛的疗效和不良反应进行观察。结果:A组患者维持剂量≤60 m g/d和>60 m g/d的有效率分别为83.3%、85.7%,而B组患者分别为81.8%、87.5%,两组无明显差异(P>0.05);并且进一步对A、B两组不同的疼痛分级、不同的疼痛类型的止痛效果分析,均无统计学差异(P>0.05);另外,A、B两组的不良反应如恶心、呕吐、便秘、排尿困难、嗜睡等均无统计学差异(P>0.05)。结论:经口服和直肠应用TM的疗效和不良反应相近,对重症且进食、进水、吞咽困难者或肠道肿瘤致肠梗阻者经直肠应用TM是有效、安全、方便的镇痛方法之一。
Objective：To observe the therapeutic effect and the adverse effect of oxycodone hydrochloride controlled-release tablets for moderate and severe cancer pain by oral and rectal administration. Method ：A total of 61 cases with moderate and severe cancer pain were grouped A and B randomly. Group A which was 31 cases were treated with oxycodone hydrochloride controlled-release tablets by oral administration,and group B which was 30 cases were treated with oxycodone hydrochloride conti＇olled-release tablets by rectal administration, Results ：Two groups received a maintenance dosage of ≤60 mg/d and 〉60 mg/d,effective rate of group A was 83.3% and 85.7% ,group B was 81.8% and 87.5% ,There was no significant difference between two groups （P〉0. 05）. There was no significant difference between two groups in pain classfication,pain type and analgesic effect and adverse effect such as nausea,vomit ,constipation,dy- suresia lethargy（P〉 0. 05）. Conclusion：The therapeutic effect and the adverse effect of oxycodone hydrochloride controlled-release tablets by oral and rectal administration are close to each other. Rectal administration is an effective ,safe and convenient analgesic method to serere cases accompanying diffculty of eating,dranking water and swallowing or intestinal obstruction caused by tumor.
出处
《中国误诊学杂志》
CAS
2009年第29期7057-7059,共3页
Chinese Journal of Misdiagnostics
